Transformation of Feature Selectivity From Membrane Potential to Spikes in the Mouse Superior Colliculus.
Transformation of Feature Selectivity From Membrane Potential to Spikes in the Mouse Superior Colliculus.
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DOI：
10.3389/fncel.2018.00163
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发表时间：
2018
影响因子：
5.3
通讯作者：
Cang J
中科院分区：
文献类型：
--
作者：
Shi X;Jin Y;Cang J
视觉系统中的神经元对刺激特征（如方向和方向）表现出不同程度的选择性。这种特征选择性是由复杂的电路和突触机制产生和处理的。这一过程的一个关键因素是从膜电位（Vm）到单个神经元峰值的输入输出转换。在这里，我们使用体内全细胞记录来研究小鼠上丘（SC）表面神经元视觉特征选择性的Vm-to-spike转化。正如从峰值阈值效应所预期的那样，方向和取向选择性从Vm到峰值响应增加。这种增加的程度是高度可变的，有趣的是，它与记录的神经元的感受野大小相关。我们发现Vm和尖峰速率之间的关系以及Vm动态和尖峰起始之间的关系也与接受野大小相关，这可能有助于观察到特征选择性的输入输出转换。总之，我们的发现为理解小鼠SC中的信息加工和视觉转换提供了有用的信息。
Neurons in the visual system display varying degrees of selectivity for stimulus features such as orientation and direction. Such feature selectivity is generated and processed by intricate circuit and synaptic mechanisms. A key factor in this process is the input-output transformation from membrane potential (Vm) to spikes in individual neurons. Here, we use in vivo whole-cell recording to study Vm-to-spike transformation of visual feature selectivity in the superficial neurons of the mouse superior colliculus (SC). As expected from the spike threshold effect, direction and orientation selectivity increase from Vm to spike responses. The degree of this increase is highly variable, and interestingly, it is correlated with the receptive field size of the recorded neurons. We find that the relationships between Vm and spike rate and between Vm dynamics and spike initiation are also correlated with receptive field size, which likely contribute to the observed input-output transformation of feature selectivity. Together, our findings provide useful information for understanding information processing and visual transformation in the mouse SC.
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