The evolution of poxvirus vaccines.
The evolution of poxvirus vaccines.
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DOI：
10.3390/v7041726
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发表时间：
2015-04-07
期刊：
影响因子：
--
通讯作者：
Esteban M
中科院分区：
文献类型：
--
作者：
Sánchez-Sampedro L;Perdiguero B;Mejías-Pérez E;García-Arriaza J;Di Pilato M;Esteban M
在200多年前爱德华詹纳建立人类疫苗接种后，减毒痘病毒成为遏制其家族中最致命病毒的关键角色：天花病毒（VARV），天花的病原体。牛痘病毒（CPXV）和马痘病毒（HSPV）被广泛用于这一目的，在牛和人类中传代，直到牛痘病毒（VACV）的出现，该病毒用于旨在根除疾病的最后运动，这是世界卫生组织（WHO）在1980年完成的一项奋进。从那时起，用于疫苗接种的自然进化株被引入研究实验室，在那里产生了VACV和其他具有改善安全性的痘病毒。重组DNA技术沿着该病毒家族的DNA基因组特征使得能够产生针对异源疾病的疫苗，并且痘病毒基因的特异性插入和缺失产生了具有新特性的更广谱的经修饰的病毒，这些新特性增加了它们作为疫苗载体的免疫原性和安全性。在这篇综述中，我们强调了痘病毒疫苗的演变，从第一代到目前的状态，指出不同的疫苗是如何出现的，以及在开发针对各种疾病的更合理的疫苗时正在跟进的方法。
After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, passaged in cattle and humans until the appearance of vaccinia virus (VACV), which was used in the final campaigns aimed to eradicate the disease, an endeavor that was accomplished by the World Health Organization (WHO) in 1980. Ever since, naturally evolved strains used for vaccination were introduced into research laboratories where VACV and other poxviruses with improved safety profiles were generated. Recombinant DNA technology along with the DNA genome features of this virus family allowed the generation of vaccines against heterologous diseases, and the specific insertion and deletion of poxvirus genes generated an even broader spectrum of modified viruses with new properties that increase their immunogenicity and safety profile as vaccine vectors. In this review, we highlight the evolution of poxvirus vaccines, from first generation to the current status, pointing out how different vaccines have emerged and approaches that are being followed up in the development of more rational vaccines against a wide range of diseases.
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影响因子：
5.4
作者：
Abel, Kristina;Martinez, Joy;Barry, Peter A.
通讯作者：
Barry, Peter A.
影响因子：
12.4
作者：
Antrobus, Richard D.;Berthoud, Tamara K.;Gilbert, Sarah C.
通讯作者：
Gilbert, Sarah C.
DOI：
10.3390/v6072735
发表时间：
2014-07-17
期刊：
Viruses
影响因子：
--
作者：
Altenburg AF;Kreijtz JH;de Vries RD;Song F;Fux R;Rimmelzwaan GF;Sutter G;Volz A
通讯作者：
Volz A
影响因子：
12.4
作者：
Adamina, Michel;Rosenthal, Rachel;Zajac, Paul
通讯作者：
Zajac, Paul
影响因子：
5.5
作者：
Abraham, JD;Himoudi, N;Kieny, MP
通讯作者：
Kieny, MP