Genetic influences on handedness: data from 25,732 Australian and Dutch twin families.
Genetic influences on handedness: data from 25,732 Australian and Dutch twin families.
复制标题
DOI：
10.1016/j.neuropsychologia.2008.09.005
复制
发表时间：
2009-01
期刊：
影响因子：
2.6
通讯作者：
Boomsma DI
中科院分区：
文献类型：
--
作者：
Medland SE;Duffy DL;Wright MJ;Geffen GM;Hay DA;Levy F;van-Beijsterveldt CE;Willemsen G;Townsend GC;White V;Hewitt AW;Mackey DA;Bailey JM;Slutske WS;Nyholt DR;Treloar SA;Martin NG;Boomsma DI
利手性指的是双手在技能或优先使用方面的一贯不对称，与大脑中其他功能（如语言）的偏侧化有关。由于普遍缺乏发现显著影响的统计能力，先前关于利手性的双胞胎研究得出了不一致的结果。在这里，我们展示了对澳大利亚和荷兰双胞胎及其兄弟姐妹（来自25,732个家庭的54,270人）进行的一项大型国际合作研究的分析结果（通过写作/绘画或自我报告进行评估）。结合已知协变量（性别、出生年份和出生体重）影响的最大似然分析显示，没有激素转移、镜像或双胞胎特异性影响的证据。在合子组之间或双胞胎和他们的单胎兄弟姐妹之间，患病率也没有差异。与之前的荟萃分析一致，可加性遗传效应约占方差的四分之一（24.64%）（95% CI 20.17, 27.09%），其余部分由非共享环境影响造成。本文讨论了这些发现对利手性作为主要表型和作为连锁和关联分析的协变量的影响。
Handedness refers to a consistent asymmetry in skill or preferential use between the hands and is related to lateralization within the brain of other functions such as language. Previous twin studies of handedness have yielded inconsistent results resulting from a general lack of statistical power to find significant effects. Here we present analyses from a large international collaborative study of handedness (assessed by writing/drawing or self report) in Australian and Dutch twins and their siblings (54,270 individuals from 25,732 families). Maximum likelihood analyses incorporating the effects of known covariates (sex, year of birth and birth weight) revealed no evidence of hormonal transfer, mirror imaging or twin specific effects. There were also no differences in prevalence between zygosity groups or between twins and their singleton siblings. Consistent with previous meta-analyses, additive genetic effects accounted for about a quarter (24.64%) of the variance (95% CI 20.17, 27.09%) with the remainder accounted for by non-shared environmental influences. The implications of these findings for handedness both as a primary phenotype and as a covariate in linkage and association analyses are discussed.
登录
查看更多内容
DOI：
10.1111/j.2044-8317.1977.tb00722.x
发表时间：
1977-01-01
影响因子：
2.6
作者：
EAVES, LJ;LAST, K;JINKS, JL
通讯作者：
JINKS, JL
影响因子：
5.4
作者：
Basso, O;Olsen, J;Christensen, K
通讯作者：
Christensen, K
影响因子：
2.6
作者：
Elias, LJ;Bryden, MP;Bulman-Fleming, MB
通讯作者：
Bulman-Fleming, MB
影响因子：
1.4
作者：
Elias, L J;Bryden, M P
通讯作者：
Bryden, M P
影响因子：
4.5
作者：
Klar, AJS
通讯作者：
Klar, AJS