Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia.
Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia.
复制标题
青少年和成年首发精神分裂症患者阴性症状与神经认知功能的关系
DOI：
10.1186/s12888-016-1052-x
复制
发表时间：
2016-10-06
期刊：
影响因子：
4.4
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Huang M;Huang Y;Yu L;Hu J;Chen J;Jin P;Xu W;Wei N;Hu S;Qi H;Xu Y
背景本研究旨在探讨首发精神分裂症青少年和成年患者阴性症状与神经认知缺陷之间联系的差异。精神分裂症是一种精神障碍，通常以阳性和阴性症状、情绪表达减少、兴奋状态和认知能力差为特征。据报道，精神分裂症患者阴性症状的严重程度与生活质量差、功能能力弱、家庭负担重相关，而不是与阳性症状的严重程度相关。先前的研究表明，精神分裂症患者的阴性症状严重程度与神经认知缺陷之间存在相关性。方法本研究包括 92 名首发精神分裂症患者（33 名青少年和 59 名成人）和 57 名年龄和教育水平相匹配的健康人。使用标准化问卷评估神经认知功能和临床症状。结果与健康人相比，首发精神分裂症患者在大多数神经心理学评估中表现出神经认知缺陷。在控制教育水平变量的情况下，首发精神分裂症青少年患者的负因子得分与在试验测试第 1 部分 (r= .646) 和第 2 部分 (r= .663) 上花费的时间较多密切相关，与威斯康星卡片分类测试中更多的持续错误 (r= .425) 和正确试验较少呈中度相关 2 (r= −.425) 的连续性能测试。然而，在成年患者中没有发现这种相关性。结论本研究表明首发精神分裂症患者的阴性症状与大多数神经认知功能之间存在显着相关性，在青少年患者中相关性更强。试验注册试验注册号为ChiCTR-COC-14005302，回顾性注册于2014年1月5日。
BackgroundThis study aimed to explore differences in links between negative symptoms and neurocognitive deficits in adolescent and adult patients with first-episode schizophrenia. Schizophrenia is a mental disorder often characterized by positive and negative symptoms, reduced emotional expression, excitatory status, and poor cognitive ability. The severity of negative symptoms in patients with schizophrenia was reported to be more related to poor quality of life, weak functional ability, and heavy burden from families than with the severity of positive symptoms. Previous studies suggested correlations between the severity of negative symptoms in patients with schizophrenia and neurocognitive deficits.MethodsThis study included 92 patients (33 adolescents and 59 adults) with first-episode schizophrenia and 57 healthy people matched by age and education level. Neurocognitive functions and clinical symptoms were assessed using a standardized questionnaire.ResultsPatients with first-episode schizophrenia showed neurocognitive deficits in most neuropsychological assessments compared with healthy people. With the variable of education level controlled, the negative factor score of adolescent patients with first-episode schizophrenia was strongly correlated with more time spent in part 1 (r= .646) and part 2 (r= .663) of the trail making test, and moderately correlated to more perseverative errors (r= .425) of the Wisconsin card sorting test and fewer correct trials 2 (r= −.425) of the continuous performance test. However, no such correlations were found in adult patients.ConclusionsThis study indicated significant correlations between negative symptoms and most neurocognitive functions in patients with first-episode schizophrenia, with a stronger correlation in adolescent patients.Trial registrationThe trial registration number is ChiCTR-COC-14005302 , while retrospectively registered on January 5, 2014.
登录
查看更多内容
影响因子：
2.6
作者：
Greve, KW;Stickle, TR;Stanford, MS
通讯作者：
Stanford, MS
影响因子：
4.5
作者：
Rodriguez-Jimenez, Roberto;Bagney, Alexandra;Palomo, Tomas
通讯作者：
Palomo, Tomas
影响因子：
4.5
作者：
Lançon, C;Auquier, P;Reine, G
通讯作者：
Reine, G
影响因子：
64.8
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
影响因子：
14.8
作者：
Bowie, Christopher R.;Harvey, Philip D.
通讯作者：
Harvey, Philip D.