T(2) preparation method for measuring hyperemic myocardial O(2) consumption: in vivo validation by positron emission tomography.
T(2) preparation method for measuring hyperemic myocardial O(2) consumption: in vivo validation by positron emission tomography.
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DOI：
10.1002/jmri.22322
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发表时间：
2011-02
影响因子：
4.4
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
McCommis, Kyle S.;O'Connor, Robert;Abendschein, Dana R.;Muccigrosso, David;Gropler, Robert J.;Zheng, Jie
目的：验证一种新的用正电子发射断层扫描（PET）定量药理学应激时心肌局部氧耗的方法。T2制备的梯度回声序列被修改以测量单次屏气内的心肌T2。随机选取6只beagle犬进行冠状动脉狭窄诱导。静息和多巴酚丁胺或双嘧达莫引起充血时，分别用T2显像和第一次灌注显像进行磁共振成像（MRI）实验。心肌血流量（MBF）使用先前开发的无模型算法进行量化。充血性心肌O2提取分数（OEF）和消耗（MVO2）使用先前建立的双室模型计算。在同一天使用11c -醋酸盐和15o -水进行PET成像，以验证OEF、MBF和MVO2的测量结果。T2制图序列测量局部心肌T2，重复性为2.3%。基于心肌节段分析，MRI测得的MBF与PET测得的MBF密切相关（R2 = 0.85, n = 22）。充血OEF （R2 = 0.90, n = 9， PET - MRI平均差值= - 2.4%）与MVO2 （R2 = 0.83, n = 7，平均差值= 4.2%）的相关系数相似。t2制备成像方法可以定量估计局部心肌氧合，准确度相对较好。该方法的精度还有待提高。
To validate a new T2-prepared method for the quantification of regional myocardial O2 consumption during pharmacologic stress with positron emission tomography (PET). A T2 prepared gradient-echo sequence was modified to measure myocardial T2 within a single breath-hold. Six beagle dogs were randomly selected for the induction of coronary artery stenosis. Magnetic resonance imaging (MRI) experiments were performed with the T2 imaging and first-pass perfusion imaging at rest and during either dobutamine- or dipyridamole-induced hyperemia. Myocardial blood flow (MBF) was quantified using a previously developed model-free algorithm. Hyperemic myocardial O2 extraction fraction (OEF) and consumption (MVO2) were calculated using a two-compartment model developed previously. PET imaging using 11C-acetate and 15O-water was performed in the same day to validate OEF, MBF, and MVO2 measurements. The T2-prepared mapping sequence measured regional myocardial T2 with a repeatability of 2.3%. By myocardial segment-basis analysis, MBF measured by MRI is closely correlated with that measured by PET (R2 = 0.85, n = 22). Similar correlation coefficients were observed for hyperemic OEF (R2 = 0.90, n = 9, mean difference of PET − MRI = −2.4%) and MVO2 (R2 = 0.83, n = 7, mean difference = 4.2%). The T2-prepared imaging method may allow quantitative estimation of regional myocardial oxygenation with relatively good accuracy. The precision of the method remains to be improved.
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