Determinants of intrathoracic adipose tissue volume and associations with cardiovascular disease risk factors in Amish.
Determinants of intrathoracic adipose tissue volume and associations with cardiovascular disease risk factors in Amish.
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DOI：
10.1016/j.numecd.2013.09.015
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Mitchell BD
中科院分区：
文献类型：
--
作者：
Liu X;Post WS;McLenithan J;Terrin M;Magder L;Zeb I;Budoff M;Mitchell BD
假设胸内脂肪可能对冠状动脉血管产生局部影响，我们评估了909名相对健康的阿米什成年人的胸内脂肪体积及其两个亚组分与冠状动脉钙化（CAC）的关系。通过电子束CT扫描测量胸内脂肪，包括心脏表面和内脏心外膜（心外膜脂肪）之间的脂肪和心脏周围但纤维性心外膜外的脂肪（心包脂肪）。我们在多元回归模型中检验了胸内脂肪量与心血管疾病危险因素之间的关系。心外膜和心包间室脂肪量与体重指数高度相关。在年龄调整后的性别分层模型中，CAC范围和CAC存在（Agatston评分>0）与胸内脂肪体积增加无关（p >.1）。在年龄调整后的性别分层模型中，胸内脂肪体积与较高的收缩压/舒张压、脉压、空腹血糖、胰岛素、甘油三酯和较低的高密度脂蛋白胆固醇显著相关（p<0.05）。然而，在进一步调整体重指数后，相关性减弱。这些数据并不能支持胸内脂肪在CAC发展中的重要作用。
Hypothesizing that intrathoracic fat might exert local effects on the coronary vasculature, we assessed the association of intrathoracic fat volume and its two subcomponents with coronary artery calcification (CAC) in 909 relatively healthy Amish adults. Intrathoracic fat, which is comprised of fat between the surface of the heart and the visceral epicardium (epicardial fat) and fat around the heart but outside of the fibrous pericardium (pericardial fat), was measured from electron beam CT scans. We examined the association between intrathoracic fat volume and cardiovascular disease risk factors in multivariate regression model. Fat volume in the epicardial and pericardial compartments were highly correlated with each other and with body mass index. Neither CAC extent nor CAC presence (Agatston score>0) was associated with increased intrathoracic fat volume in sex-stratified models adjusting for age (p>0.10). Intrathoracic fat volume was significantly correlated with higher systolic/diastolic blood pressure, pulse pressure, fasting glucose, insulin, triglyceride and lower high-density lipoprotein cholesterol in sex-stratified models adjusting for age (p<0.05). However, associations were attenuated after further adjustment for body mass index. These data do not provide support for a significant role for intrathoracic fat in the development of CAC.
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影响因子：
4.2
作者：
Shen, H.;Bielak, L. F.;Mitchell, B. D.
通讯作者：
Mitchell, B. D.
影响因子：
4.8
作者：
Sacks, Harold S.;Fain, John N.
通讯作者：
Fain, John N.
影响因子：
37.8
作者：
Mazurek, T;Zhang, LF;Shi, Y
通讯作者：
Shi, Y
影响因子：
9.3
作者：
Baker, Adam R.;da Silva, Nancy F.;Quinn, David W.;Harte, Alison L.;Pagano, Domenico;Bonser, Robert S.;Kumar, Sudhesh;McTernan, Philip G.
通讯作者：
McTernan, Philip G.
影响因子：
37.8
作者：
Post, Wendy;Bielak, Lawrence F.;Mitchell, Braxton D.
通讯作者：
Mitchell, Braxton D.