Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease.
Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease.
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DOI：
10.1186/1475-2840-5-1
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发表时间：
2006-01-13
影响因子：
9.3
通讯作者：
McTernan, Philip G.
中科院分区：
文献类型：
--
作者：
Baker, Adam R.;da Silva, Nancy F.;Quinn, David W.;Harte, Alison L.;Pagano, Domenico;Bonser, Robert S.;Kumar, Sudhesh;McTernan, Philip G.
炎症可导致心血管疾病，并随着肥胖的增加而加重，特别是网膜肥胖;然而，心外膜脂肪的作用知之甚少。在这些研究中，使用定量RT-PCR评估了冠状动脉旁路移植术（CABG）患者心外膜脂肪活检中炎症标志物的表达。此外，还评估了慢性药物（包括他汀类药物）以及围手术期葡萄糖、胰岛素和钾输注对基因表达的影响。测定循环中的瘦素、CRP、脂联素和瘦素水平以评估炎症。脂联素、脂联素和其他脂肪细胞因子mRNA的表达与网膜脂肪相当。心外膜CD 45表达显著高于对照储库（p < 0.01），表明巨噬细胞的显著浸润。与对照腹部贮库相比，他汀治疗的患者显示出显著较低的心外膜IL-6 mRNA表达（p < 0.001）。冠状动脉旁路移植术患者的血清CRP水平明显高于对照组，（对照组：1.28 ± 1.57 μg/mL vs CABG组：9.11 ± 15.7 μg/mL; p < 0.001），（对照组：10.53 ± 0.81 ng/mL vs CABG组：16.8 ± 1.69 ng/mL; p < 0.01）和脂联素水平显著降低（对照：29.1 ± 14.8 μg/mL vs CABG：11.9 ± 6.0 μg/mL; p < 0.05）。心外膜和网膜脂肪表现出大致相当的致病性mRNA谱，这可能部分由巨噬细胞浸润到心外膜脂肪中引起。这项研究强调，慢性炎症发生局部以及全身可能进一步促进冠状动脉疾病的发病机制。
Inflammation contributes to cardiovascular disease and is exacerbated with increased adiposity, particularly omental adiposity; however, the role of epicardial fat is poorly understood. For these studies the expression of inflammatory markers was assessed in epicardial fat biopsies from coronary artery bypass grafting (CABG) patients using quantitative RT-PCR. Further, the effects of chronic medications, including statins, as well as peri-operative glucose, insulin and potassium infusion, on gene expression were also assessed. Circulating resistin, CRP, adiponectin and leptin levels were determined to assess inflammation. The expression of adiponectin, resistin and other adipocytokine mRNAs were comparable to that in omental fat. Epicardial CD45 expression was significantly higher than control depots (p < 0.01) indicating significant infiltration of macrophages. Statin treated patients showed significantly lower epicardial expression of IL-6 mRNA, in comparison with the control abdominal depots (p < 0.001). The serum profile of CABG patients showed significantly higher levels of both CRP (control: 1.28 ± 1.57 μg/mL vs CABG: 9.11 ± 15.7 μg/mL; p < 0.001) and resistin (control: 10.53 ± 0.81 ng/mL vs CABG: 16.8 ± 1.69 ng/mL; p < 0.01) and significantly lower levels of adiponectin (control: 29.1 ± 14.8 μg/mL vs CABG: 11.9 ± 6.0 μg/mL; p < 0.05) when compared to BMI matched controls. Epicardial and omental fat exhibit a broadly comparable pathogenic mRNA profile, this may arise in part from macrophage infiltration into the epicardial fat. This study highlights that chronic inflammation occurs locally as well as systemically potentially contributing further to the pathogenesis of coronary artery disease.
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影响因子：
8.7
作者：
Hotta, K;Funahashi, T;Matsuzawa, Y
通讯作者：
Matsuzawa, Y
影响因子：
2.8
作者：
Linz, W;Wiemer, G;Scholkens, BA
通讯作者：
Scholkens, BA
影响因子：
37.8
作者：
Mazurek, T;Zhang, LF;Shi, Y
通讯作者：
Shi, Y
影响因子：
3.5
作者：
Nesto, R
通讯作者：
Nesto, R
DOI：
10.1016/j.bbrc.2003.12.104
发表时间：
2004-02-06
影响因子：
3.1
作者：
Kawanami, D;Maemura, K;Nagai, R
通讯作者：
Nagai, R