Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
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DOI：
10.1016/j.chom.2018.06.007
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发表时间：
2018-07-11
影响因子：
30.3
通讯作者：
Xavier RJ
中科院分区：
文献类型：
--
作者：
Yassour M;Jason E;Hogstrom LJ;Arthur TD;Tripathi S;Siljander H;Selvenius J;Oikarinen S;Hyöty H;Virtanen SM;Ilonen J;Ferretti P;Pasolli E;Tett A;Asnicar F;Segata N;Vlamakis H;Lander ES;Huttenhower C;Knip M;Xavier RJ
婴儿肠道中细菌群落的获得影响免疫教育和疾病易感性。我们在一个由44名婴儿及其母亲组成的前瞻性出生队列中比较了家庭内部和家庭之间的细菌菌株，这些婴儿及其母亲在每个孩子出生后的头几个月进行了纵向采样。我们确定了母婴细菌传播事件，并描述了家庭特异性抗生素耐药基因的发病率。我们在多个物种中观察到两种遗传模式，通常母亲的优势菌株会传播给孩子，但偶尔她的次要菌株会在婴儿肠道中定植。在B.当母亲的优势品系中没有淀粉利用基因簇时，在孩子中鉴定出了淀粉利用基因簇，这表明母亲的次级品系在婴儿肠道中具有选择性优势。我们的研究结果揭示了高分辨率的母婴细菌传播事件，并深入了解了婴儿肠道的早期定植。Yassour等人使用来自44对母亲/儿童的纵向宏基因组测序，表征了母亲到儿童的菌株传播模式。虽然母亲的优势菌株往往是遗传的，但也观察到非显性的次级菌株传播。微生物功能分析表明，遗传的母体次级菌株可能具有选择性优势，以殖民婴儿的肠道。
Bacterial community acquisition in the infant gut impacts immune education and disease susceptibility. We compared bacterial strains across and within families in a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child’s life. We identified mother-to-child bacterial transmission events and describe the incidence of family-specific antibiotic resistance genes. We observed two inheritance patterns across multiple species, where often the mother’s dominant strain is transmitted to the child, but occasionally her secondary strains colonize the infant gut. In families where the secondary strain of B. uniformis was inherited, a starch utilization gene cluster that was absent in the mother’s dominant strain was identified in the child, suggesting the selective advantage of a mother’s secondary strain in the infant gut. Our findings reveal mother-to-child bacterial transmission events at high-resolution and give insights into early colonization of the infant gut. Using longitudinal metagenomic sequencing from 44 mother/child pairs, Yassour et al. characterized mother-to-child strain transmission patterns. While mothers’ dominant strains were often inherited, nondominant secondary strain transmissions were also observed. Microbial functional analysis reveal inherited maternal secondary strains may have a selective advantage to colonize infant guts.
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影响因子：
30.3
作者：
Cahenzli J;Köller Y;Wyss M;Geuking MB;McCoy KD
通讯作者：
McCoy KD
DOI：
10.1126/science.1219328
发表时间：
2012-04-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Olszak T;An D;Zeissig S;Vera MP;Richter J;Franke A;Glickman JN;Siebert R;Baron RM;Kasper DL;Blumberg RS
通讯作者：
Blumberg RS
影响因子：
46.9
作者：
Luo C;Knight R;Siljander H;Knip M;Xavier RJ;Gevers D
通讯作者：
Gevers D
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
30.3
作者：
Marcobal A;Barboza M;Sonnenburg ED;Pudlo N;Martens EC;Desai P;Lebrilla CB;Weimer BC;Mills DA;German JB;Sonnenburg JL
通讯作者：
Sonnenburg JL