Impact of circulating miRNA-373 on breast cancer diagnosis through targeting VEGF and cyclin D1 genes.
Impact of circulating miRNA-373 on breast cancer diagnosis through targeting VEGF and cyclin D1 genes.
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通过靶向VEGF和细胞周期蛋白D1基因，循环miRNA-373对乳腺癌诊断的影响。
DOI：
10.1186/s43141-021-00174-7
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发表时间：
2021-06-05
期刊：
影响因子：
--
通讯作者：
Swellam M
中科院分区：
文献类型：
--
作者：
Bakr NM;Mahmoud MS;Nabil R;Boushnak H;Swellam M
乳腺癌是女性常见的原发性肿瘤。因此，迫切需要改善BC的早期预测和诊断。因此，本研究的目的是分析乳腺癌妇女中miRNA-373及其靶基因（包括血管内皮生长因子（VEGF）和细胞周期蛋白D1）的表达水平。与对照组中的下调相比，在BC患者中观察到miRNA-373及其靶基因的上调，随后是良性乳腺病变患者。miRNA-373的表达水平与所有临床特征之间存在显著相关性。在其靶基因与除激素状态外的所有临床病理特征之间观察到相同的关联。miRNA-373与这两个基因之间的相关性显著。我们的研究结果证明，miRNA-373作为一种癌细胞标记物，通过靶向VEGF和cyclin D1，将成为BC诊断和预后的重要生物标志物。
Breast cancer (BC) is the common primary tumor among females. Hence, there is an urgent need to improve the early prediction and diagnosis of BC. For that reason, the object of the current study is to analyze the expression levels of miRNA-373 and its target genes including vascular endothelial growth factor (VEGF) and cyclin D1 in women with BC. Upregulation of miRNA-373 and its target genes was observed in BC patients followed by patients with benign breast lesions compared to downregulation in controls. There was a significant association between the expression level of miRNA-373 and all clinical features. The same associations were observed between its target genes and all clinico-pathological features except hormonal status. The correlation between miRNA-373 and both genes was significant. Our results prove that miRNA-373, as an oncomir, would be a vital biomarker for BC diagnosis and prognosis by targeting both VEGF and cyclin D1.
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