Association between serum GDF-15, myostatin, and sarcopenia in cardiovascular surgery patients.
Association between serum GDF-15, myostatin, and sarcopenia in cardiovascular surgery patients.
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DOI：
10.1016/j.ijcha.2022.101114
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发表时间：
2022-10
影响因子：
2.9
通讯作者：
Nakajima, Toshiaki
中科院分区：
文献类型：
--
作者：
Nishikawa, Riichi;Fukuda, Taira;Haruyama, Akiko;Shibasaki, Ikuko;Yamaguchi, Suomi;Arikawa, Takuo;Obi, Syotaro;Amano, Hirohisa;Yagi, Hiroshi;Sakuma, Masashi;Abe, Shichiro;Fukuda, Hirotsugu;Toyoda, Shigeru;Nakajima, Toshiaki
肌肉生长抑素是骨骼肌群的负性调节因子。另一方面，生长分化因子(GDF)-15与较低的肌肉力量和肌肉质量有关。通过ROC曲线和多元回归分析，我们研究了心血管手术患者血清GDF-15、肌肉生长抑素和肌钙蛋白减少之间的关系。通过生物阻抗分析测量骨骼肌质量指数(SMI)、握力、伸膝力量和步行速度。采用双抗体夹心ELISA法测定患者术前血清GDF-15和Myostatin水平。骨质疏松症指数可表示为：−0.0042×−[肌肉生长抑制素]+0.0007×[GDF15]+0.0890×年龄+1.4030×性别−0.2679×体重指数−2.1186。绘制ROC曲线以确定石棺减少指数检测石棺减少的最佳界值水平。这项研究包括120名接受心血管手术的患者。SMI、握力、伸膝力量和步行速度与GDF-15呈负相关，而与肌肉生长抑素呈正相关。在多元逐步回归分析中，SMI是Myostatin的决定因素，GDF-15和myostatin都是SMI和肌肉厚度的决定因素，即使调整了年龄、性别和BMI后也是如此。ROC曲线显示，石棺减少指数是石棺减少的决定因素(截断值−为1.0634，曲线下面积为0.901，敏感性为96.9%，特异性为70.9%)。在接受心血管手术的患者中，GDF-15和肌肉生长抑制素与骨骼肌量相关，但这些相关性是不同的。根据GDF-15和myostatin水平计算的骨量减少指数可能是骨量减少的生物标志物。
Myostatin is a negative regulator of skeletal muscle mass. On the other hand, growth differentiation factor (GDF)-15 is associated with lower muscle strength and muscle mass. We investigated the relationship between serum GDF-15, myostatin, and sarcopenia in patients receiving cardiovascular surgery through a ROC curve and a multivariate regression analysis. Skeletal muscle mass index (SMI) by bioelectrical impedance analysis, hand-grip strength, knee extension strength, and walking speed were measured. Preoperative serum GDF-15 and myostatin levels were determined by ELISA. The sarcopenia index could be expressed as: −0.0042 × [myostatin] + 0.0007 × [GDF-15] + 0.0890 × age + 1.4030 × sex − 0.2679 × body mass index (BMI) − 2.1186. A ROC curve was plotted to identify the optimal cutoff level of the sarcopenia index to detect sarcopenia. 120 patients receiving cardiovascular surgery were included in the study. SMI, hand-grip strength, knee extension strength, and walking speed inversely correlated with GDF-15, but positively correlated with myostatin. In the multivariate stepwise regression analysis, SMI was a determinant of myostatin, and both GDF-15 and myostatin were determinants of SMI and muscle thickness, even after adjustment for age, sex, and BMI. A ROC curve showed that the sarcopenia index was a determinant of sarcopenia (cutoff value −1.0634, area under the curve 0.901, sensitivity 96.9%, specificity 70.9%). GDF-15 and myostatin are associated with skeletal muscle volume in patients receiving cardiovascular surgery, but these associations are different. The sarcopenia index calculated from GDF-15 and myostatin levels may be a biomarker of sarcopenia.
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DOI：
10.1016/j.ijcha.2020.100651
发表时间：
2020-12
期刊：
International journal of cardiology. Heart & vasculature
影响因子：
--
作者：
Yazawa H;Fukuda T;Kaneda H;Waku R;Sakuma M;Matsumoto A;Toyoda S;Abe S;Nakamura F;Inoue T;Nakajima T
通讯作者：
Nakajima T
影响因子：
39.3
作者：
Fuelster, Susann;Tacke, Matthias;von Haehling, Stephan
通讯作者：
von Haehling, Stephan
DOI：
10.1016/s0735-1097(02)01736-9
发表时间：
2002-04-03
影响因子：
24
作者：
Hambrecht, R;Schulze, PC;Schuler, G
通讯作者：
Schuler, G
影响因子：
37.8
作者：
Shimura, Tetsuro;Yamamoto, Masanori;Hayashida, Kentaro
通讯作者：
Hayashida, Kentaro
影响因子：
3.5
作者：
Furihata, Takaaki;Kinugawa, Shintaro;Tsutsui, Hiroyuki
通讯作者：
Tsutsui, Hiroyuki