Impact of Mindfulness-Based Stress Reduction training on intrinsic brain connectivity.
Impact of Mindfulness-Based Stress Reduction training on intrinsic brain connectivity.
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DOI：
10.1016/j.neuroimage.2011.02.034
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发表时间：
2011-05-01
期刊：
影响因子：
5.7
通讯作者：
Naliboff, Bruce D.
中科院分区：
文献类型：
--
作者：
Kilpatrick, Lisa A.;Suyenobu, Brandall Y.;Smith, Suzanne R.;Bueller, Joshua A.;Goodman, Trudy;Creswell, J. David;Tillisch, Kirsten;Mayer, Emeran A.;Naliboff, Bruce D.
正念意识和正念冥想训练对身心健康的有益影响被认为部分是通过改变潜在的大脑过程来实现的。功能连接磁共振成像(FcMRI)可以识别大脑中的功能网络。它已经被用来研究依赖状态的活动，并且非常适合于研究冥想等状态。我们应用fcMRI来确定基于正念的压力减轻(MBSR)训练在改变内在连接网络(ICN)方面是否有效。健康女性被随机分配参加为期8周的基于正念的压力减轻(MBSR)培训课程或8周的等待期。8周后，在受试者闭上眼睛休息的情况下采集fMRI数据(1.5T)，并指示注意扫描仪环境的声音。使用组独立成分分析来研究训练相关的功能连接性的变化。与MBSR相关的功能连接性的显著差异主要存在于听觉/突显网络和视觉内侧网络。与对照组的研究结果相比，MBSR受试者表现出(1)听觉和视觉网络内的功能连接增加，(2)听觉皮质和与注意和自我参照过程相关的区域之间的功能连接增加，(3)听觉和视觉皮质之间的反相关程度更高，(4)视觉皮质与注意和自我参照过程相关的区域之间的反相关程度更大。这些发现表明，8周的正念冥想训练改变了内在的功能连接，可能反映了更一致的注意力集中、增强的感觉处理和对感觉体验的反思意识。
The beneficial effects of mindful awareness and mindfulness meditation training on physical and psychological health are thought to be mediated in part through changes in underlying brain processes. Functional connectivity MRI (fcMRI) allows identification of functional networks in the brain. It has been used to examine state-dependent activity and is well-suited for studying states such as meditation. We applied fcMRI to determine if Mindfulness-Based Stress Reduction (MBSR) training is effective in altering intrinsic connectivity networks (ICNs). Healthy women were randomly assigned to participate in an 8 week Mindfulness-Based Stress Reduction (MBSR) training course or an 8 week waiting period. After 8 weeks, fMRI data (1.5 T) was acquired while subjects rested with eyes closed, with the instruction to pay attention to the sounds of the scanner environment. Group independent component analysis was performed to investigate training-related changes in functional connectivity. Significant MBSR-related differences in functional connectivity were found mainly in auditory/salience and medial visual networks. Relative to findings in the control group, MBSR subjects showed (1) increased functional connectivity within auditory and visual networks, (2) increased functional connectivity between auditory cortex and areas associated with attentional and self-referential processes, (3) greater anticorrelation between auditory and visual cortex, and (4) greater anticorrelation between visual cortex and areas associated with attentional and self-referential processes. These findings suggest that 8 weeks of mindfulness meditation training alters intrinsic functional connectivity in ways that may reflect a more consistent attentional focus, enhanced sensory processing, and reflective awareness of sensory experience.
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影响因子：
5.7
作者：
Bianciardi M;Fukunaga M;van Gelderen P;Horovitz SG;de Zwart JA;Duyn JH
通讯作者：
Duyn JH
影响因子：
4.2
作者：
Goldin, Philippe R.;Gross, James J.
通讯作者：
Gross, James J.
影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
DOI：
10.1073/pnas.0901831106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Deco, Gustavo;Jirsa, Viktor;Koetter, Rolf
通讯作者：
Koetter, Rolf