Decreased ventral striatal activity with impulse control disorders in Parkinson's disease.
Decreased ventral striatal activity with impulse control disorders in Parkinson's disease.
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DOI：
10.1002/mds.23147
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发表时间：
2010-08-15
影响因子：
8.6
通讯作者：
Weintraub, Daniel
中科院分区：
文献类型：
--
作者：
Rao, Hengyi;Mamikonyan, Eugenia;Detre, John A.;Siderowf, Andrew D.;Stern, Matthew B.;Potenza, Marc N.;Weintraub, Daniel
据报道，帕金森病（PD）中发生了一系列冲动控制障碍（ICDs）。然而，PD患者的icd在休息和冒险时发生的脑活动改变尚不清楚。我们使用动脉自旋标记（ASL）灌注功能磁共振成像（fMRI）直接量化静息脑血流量（CBF）和血氧水平依赖（BOLD）功能磁共振成像（fMRI）来测量气球模拟风险任务（BART）执行过程中对冒险的神经反应。18例PD患者，诊断为一种或多种ICD （N=9）或终生无ICD病史（N=9）。BOLD fMRI数据显示，没有ICD的PD患者在冒险过程中激活了中脑皮质边缘通路。与非ICD患者相比，ICD患者在冒险过程中右侧腹侧纹状体BOLD活性显著降低，右侧腹侧纹状体静息CBF显著降低。PD患者的icd与休息时右侧腹侧纹状体活性降低和冒险时纹状体活性降低有关，表明PD患者和非PD患者的icd可能存在共同的神经机制。因此，非PD患者的icd治疗值得PD患者合并icd的考虑。
A range of impulse control disorders (ICDs) are reported to occur in Parkinson’s disease (PD). However, alterations in brain activity at rest and during risk taking occurring with ICDs in PD are not well understood. We used both arterial spin labeling (ASL) perfusion fMRI to directly quantify resting cerebral blood flow (CBF) and blood oxygenation level dependent (BOLD) fMRI to measure neural responses to risk taking during performance on the Balloon Analogue Risk Task (BART). 18 PD patients, either with a diagnosis of one or more ICDs (N=9) or no lifetime ICD history (N=9), participated. BOLD fMRI data demonstrated that PD patients without an ICD activate the mesocorticolimbic pathway during risk taking. Compared with non-ICD patients, ICD patients demonstrated significantly diminished BOLD activity in the right ventral striatum during risk taking and significantly reduced resting CBF in the right ventral striatum. ICDs in PD are associated with reduced right ventral striatal activity at rest and diminished striatal activation during risk taking, suggesting that a common neural mechanism may underlie ICDs in individuals with PD and those without PD. Thus, treatments for ICDs in non-PD patients warrant consideration in PD patients with ICDs.
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影响因子：
8.6
作者：
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通讯作者：
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通讯作者：
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