Lampbrush Chromosomes
Lampbrush Chromosomes
复制标题
灯刷染色体
DOI：
10.1007/978-3-642-82792-1
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Professor Dr. Harold Garnet Callan
中科院分区：
文献类型：
--
作者：
Professor Dr. Harold Garnet Callan
人们在近100年前首次观察到了灯刷染色体，本讲座将对他们的研究进行历史性的回顾，特别是过去30年的研究。关于灯刷染色体的结构和功能意义存在许多争议，尽管它们的一般结构布局在经历了几次误解之后已经牢固确立，但它们的功能意义仍然存在争议。对灯刷染色体的研究在确定真核生物生殖系中的染色单体在DNA方面是单股的方面发挥了重要作用，从而揭示了C值悖论。这也有助于建立DNA双链体在染色单体的整个长度上是连续的，但DNA/组蛋白复合物是一个t间隔反射回自身以形成侧环。这种结构一度被认为是灯刷染色体的一个特殊特征，现在看来在进行致密化的染色体中广泛存在。然而，尽管试图确定那些由灯刷染色体转录的DNA部分的序列组织，这些转录物的功能仍然是一个悬而未决的问题，价值悖论仍然没有得到解决。
Lampbrush chromosomes were first observed nearly 100 years ago, and this lecture attem pts a historical survey of what has been learnt from their study, particularly th a t over the past 30 years. There have been many controversies concerning the structure and functional significance of lampbrush chromosomes, and although their general structural layout has now, after several misconceptions, been firmly established their functional significance remains controversial. Research on lampbrush chromosomes played a significant part in establishing tha t chromatids in the germ lines of eukaryotic organisms are unineme in regard to DNA, and thereby exposed the C-value paradox. I t also helped to establish th a t a DNA duplex is continuous throughout the length of a chromatid, but th a t the DNA/histone complex is a t intervals reflected back on itself to form lateral loops. This organization, a t one time thought to be a special feature of lampbrush chromosomes, now appears to be widespread in chromosomes undergoing compaction. However, despite attem pts to determine the sequence organization of those portions of the DNA th a t are transcribed by lampbrush chromosomes, the function of these transcripts remains an open question, and the value paradox is still unresolved.
海胆卵中克隆的多聚 (A) RNA 的散布序列组织和发育表征。
影响因子：
5.6
作者：
Posakony,JW;Flytzanis,CN;Britten,RJ;Davidson,EH
通讯作者：
Davidson,EH
海胆基因组的一个散布区域，以母体 Poly(A) RNA 和胚胎核 RNA 为代表。
影响因子：
2.7
作者：
Thomas,TL;Britten,RJ;Davidson,EH
通讯作者：
Davidson,EH
两栖类卵母细胞中散布的聚腺苷酸RNA (poly(A) RNA) 不可翻译。
影响因子：
5.6
作者：
Richter,JD;Smith,LD;Anderson,DM;Davidson,EH
通讯作者：
Davidson,EH