Establishing the Melbourne Injecting Drug User Cohort Study (MIX): rationale, methods, and baseline and twelve-month follow-up results.
Establishing the Melbourne Injecting Drug User Cohort Study (MIX): rationale, methods, and baseline and twelve-month follow-up results.
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DOI：
10.1186/1477-7517-10-11
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发表时间：
2013-06-21
影响因子：
4.4
通讯作者：
Dietze P
中科院分区：
文献类型：
--
作者：
Horyniak D;Higgs P;Jenkinson R;Degenhardt L;Stoové M;Kerr T;Hickman M;Aitken C;Dietze P
队列研究为监测行为变化和疾病传播提供了一个极好的机会。在澳大利亚，对注射吸毒者（PWID）的队列研究一般集中在老年人、治疗中的注射者，只收集了有限的结果测量数据。在这项研究中，我们特别试图招募一个年轻的样本，主要是治疗外的PWID，以研究他们的药物使用轨迹随着时间的推移。受访者驱动的抽样，传统的雪球抽样和街头推广的方法被用来招募海洛因和安非他明注射者从一个外城和两个内城地区的墨尔本，澳大利亚。收集了参与者的人口统计学和社会特征、药物使用特征、药物市场准入模式、健康和社会功能以及卫生服务利用情况等信息。每年对参与者进行跟踪。688名PWID被招募到研究中。基线时，参与者的中位年龄为27.6岁（IQR：24.4岁-29.6岁），三分之二（67%）为男性。参与者报告注射的平均时间为10.2年（范围：1.5个月至21.2年），其中11%的人注射了三年或更短的时间。大多数参与者（82%）报告最近注射过海洛因，三分之一报告在招募时参加了阿片类药物替代疗法（OST）。在12个月随访时，458名参与者（合格参与者的71%）被保留在研究中。与研究中保留的患者相比，失访患者的人口统计学和药物使用特征几乎没有差异，与在城市中心招募、男性性别和基线时提供不完整的联系信息显著相关。我们努力招募一个样本，主要是治疗外PWID是有限的药物市场的特点，在当时，波动的海洛因供应导致大量的PWID访问低阈值OST。然而，这项对澳大利亚注射者的研究将提供关于药物使用自然史的宝贵数据，沿着与注射药物使用相关的不良健康结果的风险和保护因素。全面的后续程序使参与者保持良好，减少了流失偏见。
Cohort studies provide an excellent opportunity to monitor changes in behaviour and disease transmission over time. In Australia, cohort studies of people who inject drugs (PWID) have generally focused on older, in-treatment injectors, with only limited outcome measure data collected. In this study we specifically sought to recruit a sample of younger, largely out-of-treatment PWID, in order to study the trajectories of their drug use over time. Respondent driven sampling, traditional snowball sampling and street outreach methods were used to recruit heroin and amphetamine injectors from one outer-urban and two inner-urban regions of Melbourne, Australia. Information was collected on participants’ demographic and social characteristics, drug use characteristics, drug market access patterns, health and social functioning, and health service utilisation. Participants are followed-up on an annual basis. 688 PWID were recruited into the study. At baseline, the median age of participants was 27.6 years (IQR: 24.4 years – 29.6 years) and two-thirds (67%) were male. Participants reported injecting for a median of 10.2 years (range: 1.5 months – 21.2 years), with 11% having injected for three years or less. Limited education, unemployment and previous incarceration were common. The majority of participants (82%) reported recent heroin injection, and one third reported being enrolled in Opioid Substitution Therapy (OST) at recruitment. At 12 months follow-up 458 participants (71% of eligible participants) were retained in the study. There were few differences in demographic and drug-use characteristics of those lost to follow-up compared with those retained in the study, with attrition significantly associated with recruitment at an inner-urban location, male gender, and providing incomplete contact information at baseline. Our efforts to recruit a sample of largely out-of-treatment PWID were limited by drug market characteristics at the time, where fluctuating heroin availability has led to large numbers of PWID accessing low-threshold OST. Nevertheless, this study of Australian injectors will provide valuable data on the natural history of drug use, along with risk and protective factors for adverse health outcomes associated with injecting drug use. Comprehensive follow-up procedures have led to good participant retention and limited attrition bias.
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影响因子：
4.2
作者：
Evans, Jennifer L.;Hahn, Judith A.;Page, Kimberly
通讯作者：
Page, Kimberly
影响因子：
4.2
作者：
Cottler, LB;Compton, WM;Claverie, D
通讯作者：
Claverie, D
影响因子：
11.3
作者：
Darke, Shane;Mills, Katherine;Havard, Alys
通讯作者：
Havard, Alys
影响因子：
168.9
作者：
Grimes, DA;Schulz, KF
通讯作者：
Schulz, KF
影响因子：
6
作者：
Dietze, Paul;Stoove, Mark;Burns, Lucy
通讯作者：
Burns, Lucy