Response functions for computing absorbed dose to skeletal tissues from photon irradiation--an update.
Response functions for computing absorbed dose to skeletal tissues from photon irradiation--an update.
复制标题
DOI：
10.1088/0031-9155/56/8/002
复制
发表时间：
2011-04-21
影响因子：
3.5
通讯作者：
Bolch WE
中科院分区：
文献类型：
--
作者：
Johnson PB;Bahadori AA;Eckerman KF;Lee C;Bolch WE
一套全面的光子通量剂量反应函数（DRF）的两个放射敏感的骨骼组织-活性和总浅骨髓-在15和32骨网站，分别为ICRP参考成年男性。使用UF混合成年男性体模报告的部分骨骼质量和相关电子吸收分数开发了这些功能，而UF混合成年男性体模又基于取自40岁男性尸体的松质骨的microCT图像。新的DRF扩展了1985年产生的原始七个函数，以及2007年在二次电子从海绵体逃逸的假设下计算的更新。在本研究中，它是假设光子照射的骨架将产生带电粒子的平衡在所有的海绵状区域的能量超过200千电子伏。使用DRF算法计算较高能量下活性骨髓、非活性骨髓、骨小梁和松质骨的比释动能因子，将自辐照的电子吸收分数设置为1。通过比较比释动能因子和DRF函数，导出了活性骨髓与海绵体的剂量增强因子和质量能量吸收系数（MEAC）比值。这些MEAC比值与NIST物理参考数据库提供的比值相比（平均差异为0.8%），活性骨髓的剂量增强因子与发表的著名研究中计算的值相比（平均绝对差异为1.9个百分点）。此外，活跃骨髓的剂量增强因子与浅骨髓体积分数相关性良好（R2 = 0.91）。还计算了32个骨部位的总浅骨髓的剂量增强因子
A comprehensive set of photon fluence-to-dose response functions (DRFs) are presented for two radiosensitive skeletal tissues – active and total shallow marrow – within 15 and 32 bones sites, respectively, of the ICRP reference adult male. The functions were developed using fractional skeletal masses and associated electron absorbed fractions as reported for the UF hybrid adult male phantom, which in turn is based upon microCT images of trabecular spongiosa taken from a 40-year male cadaver. The new DRFs expand upon both the original set of seven functions produced in 1985, as well as a 2007 update calculated under the assumption of secondary electron escape from spongiosa. In the present study, it is assumed that photon irradiation of the skeleton will yield charged particle equilibrium across all spongiosa regions at energies exceeding 200 keV. Kerma factors for active marrow, inactive marrow, trabecular bone, and spongiosa at higher energies are calculated using the DRF algorithm setting the electron absorbed fraction for self-irradiation to unity. By comparing kerma factors and DRF functions, dose enhancement factors and mass energy-absorption coefficient (MEAC) ratios for active marrow to spongiosa were derived. These MEAC ratios compared well with those provided by the NIST Physical Reference Data Library (mean difference of 0.8%), and the dose enhancement factors for active marrow compared favorably with values calculated in the well-known study published by (mean absolute difference of 1.9 percentage points). Additionally, dose enhancement factors for active marrow were shown to correlate well with the shallow marrow volume fraction (R2 = 0.91). Dose enhancement factors for the total shallow marrow were also calculated for 32 bone sites
登录
查看更多内容
影响因子：
3.5
作者：
Lee, Choonik;Lee, Choonsik;Bolch, Wesley E.
通讯作者：
Bolch, Wesley E.
影响因子：
2.6
作者：
KING, SD;SPIERS, FW
通讯作者：
SPIERS, FW
影响因子：
3.5
作者：
Hough M;Johnson P;Rajon D;Jokisch D;Lee C;Bolch W
通讯作者：
Bolch W
影响因子：
3.5
作者：
BEDDOE, AH;DARLEY, PJ;SPIERS, FW
通讯作者：
SPIERS, FW
影响因子：
3.5
作者：
Kramer, R;Vieira, JW;Fuelle, D
通讯作者：
Fuelle, D