An image-based skeletal dosimetry model for the ICRP reference adult male--internal electron sources.
An image-based skeletal dosimetry model for the ICRP reference adult male--internal electron sources.
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DOI：
10.1088/0031-9155/56/8/001
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发表时间：
2011-04-21
影响因子：
3.5
通讯作者：
Bolch W
中科院分区：
文献类型：
--
作者：
Hough M;Johnson P;Rajon D;Jokisch D;Lee C;Bolch W
靶组织包括与放射源性白血病相关的活性骨髓和与放射源性骨癌相关的全浅骨髓。在1 keV至10 MeV的能量范围内，考虑以下来源的单能电子发射：骨髓（活性和非活性）、小梁骨（表面和体积）和皮质骨（表面和体积）。具体吸收分数是根据MIRD模式计算的，并在论文中作为骨架平均值给出，在电子附件中以表格和图形格式报告了特定地点的值。通过对一具40岁男性尸体的全身离体CT图像（分辨率为1mm）和海绵特异性离体微CT图像（分辨率为30 μm）的详细分析，分别获得了宏观尺度上幻体皮质骨和海绵状组织的分布，以及微观尺度上幻体小梁骨和骨髓组织的分布。本工作采用的方法包括：(1)明确考虑骨髓自身剂量随骨髓细胞结构变化的变化，(2)明确考虑海绵状膜的电子逃逸，(3)明确考虑海绵状膜与皮质骨的交叉发射，(4)明确考虑ICRP在替代组织区域的变化，该区域定义了骨祖细胞的位置（从覆盖小梁和皮质表面的10 μm内质层开始），至50 μm浅骨髓层覆盖小梁和髓腔表面)。本模型中吸收部分的骨骼平均值与ICRP出版物110中发现的骨骼组织分布加权值非常一致，但在许多情况下与当前和广泛实施的内部剂量测定软件中使用的值不相容。
Target tissues include the active bone marrow, associated with radiogenic leukemia, and total shallow marrow, associated with radiogenic bone cancer. Monoenergetic electron emissions are considered over the energy range 1 keV to 10 MeV for the following sources: bone marrow (active and inactive), trabecular bone (surfaces and volumes), and cortical bone (surfaces and volumes). Specific absorbed fractions are computed according to the MIRD schema, and are given as skeletal-averaged values in the paper with site-specific values reported in both tabular and graphical format in an electronic annex. The distribution of cortical bone and spongiosa at the macroscopic dimensions of the phantom, as well as the distribution of trabecular bone and marrow tissues at the microscopic dimensions of the phantom, are imposed through detailed analyses of whole-body ex-vivo CT images (1 mm resolution) and spongiosa-specific ex-vivo microCT images (30 μm resolution), respectively, taken from a 40-year male cadaver. The method utilized in this work includes: (1) explicit accounting for changes in marrow self-dose with variations in marrow cellularity, (2) explicit accounting for electron escape from spongiosa, (3) explicit consideration of spongiosa cross-fire from cortical bone, and (4) explicit consideration of the ICRP’s change in the surrogate tissue region defining the location of the osteoprogenitor cells (from a 10-μm endosteal layer covering the trabecular and cortical surfaces, to a 50-μm shallow marrow layer covering trabecular and medullary cavity surfaces). Skeletal-averaged values of absorbed fraction in the present model are noted to be very compatible with those weighted by the skeletal tissue distributions found in the ICRP Publication 110 adult male and female voxel phantoms, but are in many cases incompatible with values used in current and widely implemented internal dosimetry software.
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影响因子：
1
作者：
Bolch, W. E.;Shah, A. P.;Eckerman, K. F.
通讯作者：
Eckerman, K. F.
影响因子：
3.5
作者：
Pafundi, Deanna;Lee, Choonsik;Bolch, Wesley
通讯作者：
Bolch, Wesley
影响因子：
9.3
作者：
Bolch, Wesley E.;Eckerman, Keith F.;Thomas, Stephen R.
通讯作者：
Thomas, Stephen R.
影响因子：
3.5
作者：
Johnson PB;Bahadori AA;Eckerman KF;Lee C;Bolch WE
通讯作者：
Bolch WE
影响因子：
2.2
作者：
Eckerman, KF;Stabin, MG
通讯作者：
Stabin, MG