Pancreatic duct replication is increased with obesity and type 2 diabetes in humans.
Pancreatic duct replication is increased with obesity and type 2 diabetes in humans.
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DOI：
10.1007/s00125-009-1556-8
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发表时间：
2010-01
期刊：
影响因子：
8.2
通讯作者：
Butler, P. C.
中科院分区：
文献类型：
--
作者：
Butler, A. E.;Galasso, R.;Matveyenko, A.;Rizza, R. A.;Dry, S.;Butler, P. C.
在高脂喂养的2型糖尿病大鼠模型中，我们注意到外分泌管复制增加。这是胰腺炎和胰腺癌的诱发因素，两者在2型糖尿病中更常见。这项研究的目的是确定肥胖和/或2型糖尿病是否与人类胰腺导管复制增加有关。我们从45个人的尸体解剖中获得胰腺，分为四组：瘦（BMI <25 kg/m2）;肥胖（BMI >27 kg/m2）;非糖尿病; 2型糖尿病。在对导管细胞标记物细胞角蛋白和Ki 67进行免疫染色后评价胰腺的复制。我们首次发现人类肥胖和2型糖尿病都与胰腺导管复制增加有关。具体来说，我们报告说，（1）胰管细胞的复制增加了10倍肥胖，（2）瘦的受试者与2型糖尿病显示了4倍的增加，胰管细胞的复制与他们的瘦非糖尿病对照。胰腺导管细胞复制在人类中响应于肥胖和2型糖尿病而增加，潜在地提供了肥胖和/或2型糖尿病患者中胰腺炎和胰腺癌风险增加的机制。
In a high-fat-fed rat model of type 2 diabetes we noted increased exocrine duct replication. This is a predisposing factor for pancreatitis and pancreatic cancer, both of which are more common in type 2 diabetes. The aim of the study reported here was to establish if obesity and/or type 2 diabetes are associated with increased pancreatic ductal replication in humans. We obtained pancreas at autopsy from 45 humans, divided into four groups: lean (BMI <25 kg/m2); obese (BMI >27 kg/m2); non-diabetic; and with type 2 diabetes. Pancreases were evaluated after immunostaining for the duct cell marker cytokeratin and Ki67 for replication. We show for the first time that both obesity and type 2 diabetes in humans are associated with increased pancreatic ductal replication. Specifically, we report that (1) replication of pancreatic duct cells is increased tenfold by obesity, and (2) lean subjects with type 2 diabetes demonstrate a fourfold increase in replication of pancreatic duct cells compared with their lean non-diabetic controls. Pancreatic duct cell replication is increased in humans in response to both obesity and type 2 diabetes, potentially providing a mechanism for the increased risk of pancreatitis and pancreatic cancer in those with obesity and/or type 2 diabetes.
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影响因子：
168.9
作者：
Renehan, Andrew G.;Tyson, Margaret;Zwahlen, Marcel
通讯作者：
Zwahlen, Marcel
影响因子：
29.4
作者：
Wagner, M;Weber, CK;Schmid, RM
通讯作者：
Schmid, RM
影响因子：
7.7
作者：
Matveyenko AV;Dry S;Cox HI;Moshtaghian A;Gurlo T;Galasso R;Butler AE;Butler PC
通讯作者：
Butler PC
影响因子：
3.1
作者：
WILLEMER, S;ADLER, G
通讯作者：
ADLER, G
影响因子：
7.7
作者：
Matveyenko, Aleksey V.;Butler, Peter C.
通讯作者：
Butler, Peter C.