Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
复制标题
DOI：
10.1007/s00125-012-2634-x
复制
发表时间：
2012-10
期刊：
影响因子：
8.2
通讯作者：
Orho-Melander, M.
中科院分区：
文献类型：
--
作者：
Hindy, G.;Sonestedt, E.;Ericson, U.;Jing, X. -J.;Zhou, Y.;Hansson, O.;Renstrom, E.;Wirfalt, E.;Orho-Melander, M.
转录因子7样2基因变体TCF 7 L2 rs7903146的T等位基因使2型糖尿病的风险增加40- 50%。由于TCF 7 L2 rs7903146与肠促胰岛素作用减弱有关，我们研究了碳水化合物、脂肪、蛋白质或纤维的饮食摄入与该变体之间的相互作用是否会影响2型糖尿病的风险。来自马尔默饮食与癌症研究（MDCS）的24，799名非糖尿病个体的队列，通过改良的饮食史方法获得饮食数据，随访12年，记录了1，649例2型糖尿病事件。对饮食五分位数分层中2型糖尿病的风险进行前瞻性分析，调整潜在的混杂因素。对MDCS中随机选择的5，216名个体的基线空腹血糖和HbA 1c水平进行了横断面分析。rs7903146增加2型糖尿病的风险（OR 1.44，95% CI 1.33，1.56，p = 4.6 × 10−19）随着膳食纤维摄入量的增加而增加（从最低到最高五分位数的OR 1.24，95% CI 1.04，1.47至OR 1.56，95% CI 1.31，1.86; p相互作用= 0.049）。仅在CC基因型携带者中，高膳食纤维摄入量与糖尿病发病率呈负相关（OR 0.74，95%CI 0.58，0.94/五分位数，p = 0.025）。T等位基因与HbA 1c升高0.027%相关（p = 0.02），这种效应随着纤维摄入量的增加而增加（从最低到最高五分位数的-0.021%至0.079%，p相互作用= 0.02）。在CC和CT中，每五分之一的高纤维摄入量与较低的HbA 1c水平相关，但在TT基因型携带者中则无关（分别为-0.036%，p = 6.5 × 10−7;-0.023%，p = 0.009;和0.012%，p = 0.52）。我们的研究表明，膳食纤维摄入量可能会改变TCF 7 L2 rs7903146与2型糖尿病发病率之间的关联，并且较高的纤维摄入量可能仅在非风险等位基因携带者中与2型糖尿病的保护相关。
The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40–50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes. A cohort of 24,799 non-diabetic individuals from the Malmö Diet and Cancer Study (MDCS), with dietary data obtained by a modified diet history method, were followed up for 12 years, with 1,649 recordings of incident type 2 diabetes made. Risk of type 2 diabetes in strata of diet quintiles was analysed prospectively adjusting for potential confounders. Cross-sectional analyses were performed on baseline fasting glucose and HbA1c levels in a subset of 5,216 randomly selected individuals from the MDCS. The elevated risk of type 2 diabetes with rs7903146 (OR 1.44, 95% CI 1.33, 1.56, p = 4.6 × 10−19) increased with higher intake of dietary fibre (OR 1.24, 95% CI 1.04, 1.47 to OR 1.56, 95% CI 1.31, 1.86 from the lowest to highest quintile; p interaction = 0.049). High intake of dietary fibre was inversely associated with diabetes incidence only among CC genotype carriers (OR 0.74, 95% CI 0.58, 0.94 per quintile, p = 0.025). The T allele was associated with 0.027% elevated HbA1c (p = 0.02) and this effect increased with higher intake of fibre (from −0.021% to 0.079% for the lowest to the highest quintile, p interaction = 0.02). Each quintile of higher fibre intake was associated with lower HbA1c levels among CC and CT but not among TT genotype carriers (−0.036%, p = 6.5 × 10−7; −0.023%, p = 0.009; and 0.012%, p = 0.52, respectively). Our study suggests that dietary fibre intake may modify the association between TCF7L2 rs7903146 and incidence of type 2 diabetes, and that higher fibre intake may associate with protection from type 2 diabetes only among non-risk allele carriers.
登录
查看更多内容
影响因子：
16.2
作者：
Nettleton JA;McKeown NM;Kanoni S;Lemaitre RN;Hivert MF;Ngwa J;van Rooij FJ;Sonestedt E;Wojczynski MK;Ye Z;Tanaka T;Garcia M;Anderson JS;Follis JL;Djousse L;Mukamal K;Papoutsakis C;Mozaffarian D;Zillikens MC;Bandinelli S;Bennett AJ;Borecki IB;Feitosa MF;Ferrucci L;Forouhi NG;Groves CJ;Hallmans G;Harris T;Hofman A;Houston DK;Hu FB;Johansson I;Kritchevsky SB;Langenberg C;Launer L;Liu Y;Loos RJ;Nalls M;Orho-Melander M;Renstrom F;Rice K;Riserus U;Rolandsson O;Rotter JI;Saylor G;Sijbrands EJ;Sjogren P;Smith A;Steingrímsdóttir L;Uitterlinden AG;Wareham NJ;Prokopenko I;Pankow JS;van Duijn CM;Florez JC;Witteman JC;MAGIC Investigators;Dupuis J;Dedoussis GV;Ordovas JM;Ingelsson E;Cupples L;Siscovick DS;Franks PW;Meigs JB
通讯作者：
Meigs JB
影响因子：
4
作者：
ELLIOTT, RM;MORGAN, LM;MARKS, V
通讯作者：
MARKS, V
影响因子：
158.5
作者：
Florez, Jose C.;Jablonski, Kathleen A.;Altshuler, David
通讯作者：
Altshuler, David
新的遗传基因座涉及禁食葡萄糖稳态及其对2型糖尿病风险的影响。
影响因子：
30.8
作者：
通讯作者：
--
人类胰岛中的开放染色质图。
影响因子：
30.8
作者：
Gaulton, Kyle J.;Nammo, Takao;Pasquali, Lorenzo;Simon, Jeremy M.;Giresi, Paul G.;Fogarty, Marie P.;Panhuis, Tami M.;Mieczkowski, Piotr;Secchi, Antonio;Bosco, Domenico;Berney, Thierry;Montanya, Eduard;Mohlke, Karen L.;Lieb, Jason D.;Ferrer, Jorge
通讯作者：
Ferrer, Jorge