Non-contrast hemodynamic imaging of Moyamoya disease with MR fingerprinting ASL: A feasibility study.
Non-contrast hemodynamic imaging of Moyamoya disease with MR fingerprinting ASL: A feasibility study.
复制标题
DOI：
10.1016/j.mri.2022.02.006
复制
发表时间：
2022-05
影响因子：
2.5
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Su P;Liu P;Pinho MC;Thomas BP;Qiao Y;Huang J;Welch BG;Lu H
磁共振指纹 (MRF) 动脉自旋标记 (ASL) 是一种非对比技术，可在单次扫描中估计多个大脑血流动力学和结构参数。本研究的目的是检验 MRF-ASL 在烟雾病中的可行性和初步效用。 MRF-ASL、传统单延迟 ASL、飞行时间 (TOF) MR 血管造影和基于对比的动态磁敏感对比 (DSC) MRI 前瞻性收集自北美一组烟雾病患者（N=21，4 名男性和 17 名女性）。 16 名健康受试者（7 名男性和 9 名女性）也接受了 MRF-ASL 扫描。比较烟雾病患者和健康对照者的脑血流量 (CBF)、推注到达时间 (BAT) 和组织 T1。将 MRF-ASL 的灌注参数与其他 MRI 序列的灌注参数进行比较。使用多元线性回归来比较 Moyamoya 和对照组之间的参数值。将 MRF-ASL 与 PCASL 和 DSC 参数进行比较时，使用了线性混合效应模型。 Spearman 等级相关系数是在将 MRF-ASL 与 MRA 等级进行比较时计算的。 P 值为 0.05 或更低被认为是显着的。与健康对照相比，烟雾病患者狭窄颈内动脉 (ICA) 区域的 BAT 延长 (P<0.001)。烟雾病患者狭窄 ICA 区域的 CBF 与健康对照的 CBF 没有差异；但在 PCA 地区，烟雾病患者的 CBF 高于对照组（P<0.01）。狭窄 ICA 区域的定量 T1 值比对照组长（P<0.05）。 MRF-ASL 估计的血流动力学参数与单延迟 ASL 和 DSC 显着相关。较长的 BAT 与 ICA 颅内动脉狭窄更严重相关。 MRF-ASL 是一种评估烟雾病患者灌注和结构异常的有前途的技术。
MR Fingerprinting (MRF) Arterial Spin Labeling (ASL) is a non-contrast technique to estimate multiple brain hemodynamic and structural parameters in a single scan. The purpose of this study is to examine the feasibility and initial utility of MRF-ASL in Moyamoya disease. MRF-ASL, conventional single-delay ASL, Time-of-flight (TOF) MR angiography, and contrast-based dynamic-susceptibility-contrast (DSC) MRI were prospectively collected from a group of Moyamoya patients in North America (N=21, 4 men and 17 women). Sixteen healthy subjects (7 men and 9 women) also underwent an MRF-ASL scan. Cerebral blood flow (CBF), bolus arrival time (BAT), and tissue T1 were compared between Moyamoya patients and healthy controls. Perfusion parameters from MRF-ASL were compared to those from other MRI sequences. Multi-linear regression was used for comparisons of parameter values between Moyamoya and control groups. Linear mixed-effects models was used when comparing MRF-ASL to PCASL and DSC parameters. Spearman’s Rank Correlation Coefficient was calculated when comparing MRF-ASL to and MRA grades. A P value of 0.05 or less was considered significant. BAT in stenotic internal carotid artery (ICA) territories was prolonged (P<0.001) in Moyamoya patients, when compared with healthy controls. CBF in stenotic ICA territories of Moyamoya patients was not different from CBF in healthy controls; but in the PCA territories, CBF in Moyamoya patients was higher (P<0.01) than controls. Quantitative T1 values in the stenotic ICA territories was longer (P<0.05) than that in controls. Hemodynamic parameters estimated from MRF-ASL were significantly correlated with single-delay ASL and DSC. Longer BAT was associated with more severe intracranial artery stenosis in ICA. MRF-ASL is a promising technique to assess perfusion and structural abnormalities in Moyamoya patients.
登录
查看更多内容
通过多个标签后延迟获取的脉冲连续3D ASL成像获得的动脉传输时间映射：与PET-CBF的比较研究：慢性闭塞性脑血管疾病患者的比较研究。
影响因子：
3.7
作者：
Tsujikawa T;Kimura H;Matsuda T;Fujiwara Y;Isozaki M;Kikuta K;Okazawa H
通讯作者：
Okazawa H
影响因子：
3.3
作者：
Su P;Mao D;Liu P;Li Y;Pinho MC;Welch BG;Lu H
通讯作者：
Lu H
影响因子：
6
作者：
Savolainen, Marika;Pekkola, Johanna;Tatlisumak, Turgut
通讯作者：
Tatlisumak, Turgut
影响因子：
2.8
作者：
Mikami, Takeshi;Suzuki, Hime;Mikuni, Nobuhiro
通讯作者：
Mikuni, Nobuhiro
具有压缩感应的磁共振血管造影：对Moyamoya病的评估。
影响因子：
3.7
作者：
Yamamoto T;Okada T;Fushimi Y;Yamamoto A;Fujimoto K;Okuchi S;Fukutomi H;Takahashi JC;Funaki T;Miyamoto S;Stalder AF;Natsuaki Y;Speier P;Togashi K
通讯作者：
Togashi K