Role of area postrema in control of torpor in Siberian hamsters.

Role of area postrema in control of torpor in Siberian hamsters.
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后区在控制西伯利亚仓鼠麻木状态中的作用。

DOI:
10.1152/ajpregu.2000.279.2.r591
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发表时间:
2000
期刊:
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子:
--
通讯作者:
Dark,J
Dark,J
中科院分区:
--
文献类型:
--
作者:
Bae,HH;Stamper,JL;Heydorn,EC;Zucker,I;Dark,J

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西伯利亚仓鼠在冬天的短短几天里会麻木,并对葡萄糖营养或食物限制做出反应。我们测试了监测代谢燃料供应的最后区和邻近的孤束核(下称AP)是否也控制了麻木的发作。对自发麻木的西伯利亚仓鼠或2-脱氧葡萄糖(2-DG)治疗后进入麻木状态的西伯利亚仓鼠进行后区消融(APx)。金黄地鼠术后持续麻木,大部分麻木特征不受APx的影响。AP不是短日照或代谢挑战引起的麻木表达所必需的。相反,用2-DG处理的仓鼠摄食量的减少被APx所抵消。在西伯利亚仓鼠中,AP似乎中介了2-DG对食物摄入量的影响,但不是麻木。
Siberian hamsters undergo torpor during the short days of winter and in response to glucoprivation or food restriction. We tested whether the area postrema and the adjacent nucleus of the solitary tract (hereafter the AP), which monitor metabolic fuel availability, also control the onset of torpor. Siberian hamsters that had manifested torpor spontaneously or had entered torpor in response to 2-deoxy-d-glucose (2-DG) treatment were subjected to area postrema ablations (APx). Hamsters continued to display torpor postoperatively; most features of torpor were unaffected by APx. The AP is not necessary for expression of torpor elicited by short day lengths or metabolic challenge. In contrast, decreases in food intake manifested by hamsters treated with 2-DG were counteracted by APx. In Siberian hamsters, the AP appears to mediate effects of 2-DG on food intake but not torpor.
叙利亚仓鼠的葡萄糖缺乏会导致不发情,而脂肪缺乏可能会导致冬眠。
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