Quadriceps muscle stimulation evokes heteronymous inhibition onto soleus with limited Ia activation compared to femoral nerve stimulation.
Quadriceps muscle stimulation evokes heteronymous inhibition onto soleus with limited Ia activation compared to femoral nerve stimulation.
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DOI：
10.1007/s00221-022-06422-7
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发表时间：
2022-09
影响因子：
2
通讯作者：
Wolf, Steven L.
中科院分区：
文献类型：
--
作者：
Lyle, Mark A.;Cuadra, Cristian;Wolf, Steven L.
来自肌纺锤体的异位兴奋反馈和来自高尔基肌腱器官的抑制性反馈以及循环抑制回路可以影响运动协调。抑制反馈的功能作用很难确定，因为在人类中使用的主要方法是神经刺激，如果不首先激活最大直径的肌肉纺锤轴突，就不能引起抑制。在这里，我们通过比较神经和肌肉刺激对持续的比目鱼肌肌电图的影响，验证了与股神经刺激相比，股四头肌刺激可以更有选择性地用于检查异位抑制的假设。运动阈值和两个较高的股神经和股四头肌刺激强度与抽搐诱发的扭矩大小相匹配。我们发现，与神经刺激相比，在股四头肌刺激期间表现出兴奋的参与者显著减少（在不同刺激强度下，14-29%对64-71%的参与者），肌肉刺激产生的异源兴奋的程度，当存在时，比神经刺激要小得多。肌肉和神经刺激导致异位抑制，随刺激引起的扭矩大小的增加而显著增加。该研究提供了新的证据，表明与神经刺激相比，肌肉刺激可以更有选择性地检测人体下肢肌肉之间的抑制性异源反馈。
Heteronymous excitatory feedback from muscle spindles and inhibitory feedback from Golgi tendon organs and recurrent inhibitory circuits can influence motor coordination. The functional role of inhibitory feedback is difficult to determine because nerve stimulation, the primary method used in humans, cannot evoke inhibition without first activating the largest diameter muscle spindle axons. Here, we tested the hypothesis that quadriceps muscle stimulation could be used to examine heteronymous inhibition more selectively when compared to femoral nerve stimulation by comparing the effects of nerve and muscle stimulation onto ongoing soleus EMG held at 20% of maximal effort. Motor threshold and two higher femoral nerve and quadriceps stimulus intensities matched by twitch evoked torque magnitudes were examined. We found that significantly fewer participants exhibited excitation during quadriceps muscle stimulation when compared to nerve stimulation (14–29% vs 64–71% of participants across stimulation intensities) and the magnitude of heteronymous excitation from muscle stimulation, when present, was much reduced compared to nerve stimulation. Muscle and nerve stimulation resulted in heteronymous inhibition that significantly increased with increasing stimulation evoked torque magnitudes. This study provides novel evidence that muscle stimulation may be used to more selectively examine inhibitory heteronymous feedback between muscles in the human lower limb when compared to nerve stimulation.
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影响因子：
2.5
作者：
HAMM, TM
通讯作者：
HAMM, TM
影响因子：
5.5
作者：
ECCLES, JC;FATT, P;KOKETSU, K
通讯作者：
KOKETSU, K
DOI：
10.1073/pnas.1419045111
发表时间：
2014-11-25
影响因子：
11.1
作者：
Akay, Turgay;Tourtellotte, Warren G.;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.
DOI：
10.1111/j.1748-1716.1964.tb10435.x
发表时间：
1964-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
JANSEN, JKS;RUDJORD, T
通讯作者：
RUDJORD, T
影响因子：
3.7
作者：
Dyer, Joseph-Omer;Maupas, Eric;de Andrade Melo, Sibele;Bourbonnais, Daniel;Fleury, Jean;Forget, Robert
通讯作者：
Forget, Robert