MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.

MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.
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DOI:
10.1002/alz.12216
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发表时间:
2021-04
期刊:
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子:
--
通讯作者:
MarkVCID Consortium
MarkVCID Consortium
中科院分区:
其他
文献类型:
--
作者:
Lu H;Kashani AH;Arfanakis K;Caprihan A;DeCarli C;Gold BT;Li Y;Maillard P;Satizabal CL;Stables L;Wang DJJ;Corriveau RA;Singh H;Smith EE;Fischl B;van der Kouwe A;Schwab K;Helmer KG;Greenberg SM;MarkVCID Consortium

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MarkVCID联盟于2016年与美国国家神经疾病和中风研究所(NINDS)和美国国家衰老研究所(NIA)达成合作协议,旨在开发和验证与血管性认知障碍和痴呆(VCID)相关的脑血管疾病的生物标志物。严格验证的生物标志物一直被认为是多中心研究的关键,以确定预防和治疗VCID的有效策略,特别是检测VCID风险增加,诊断小血管疾病及其亚型的存在,评估疾病进展或治疗反应的预后,证明候选干预措施的靶标参与或作用机制,并在治疗期间监测疾病进展。
The MarkVCID consortium was formed under cooperative agreements with the National Institute of Neurologic Diseases and Stroke (NINDS) and National Institute on Aging (NIA) in 2016 with the goals of developing and validating biomarkers for the cerebral small vessel diseases associated with the vascular contributions to cognitive impairment and dementia (VCID). Rigorously validated biomarkers have consistently been identified as crucial for multicenter studies to identify effective strategies to prevent and treat VCID, specifically to detect increased VCID risk, diagnose the presence of small vessel disease and its subtypes, assess prognosis for disease progression or response to treatment, demonstrate target engagement or mechanism of action for candidate interventions, and monitor disease progression during treatment.
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