Annals of the New York Academy of Sciences the Role of Lymph Node Sinus Macrophages in Host Defense

Annals of the New York Academy of Sciences the Role of Lymph Node Sinus Macrophages in Host Defense
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纽约科学院年鉴淋巴结窦巨噬细胞在宿主防御中的作用

DOI:
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发表时间:
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期刊:
影响因子:
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通讯作者:
M. Iannacone
M. Iannacone
中科院分区:
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文献类型:
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作者:
A. N. Acad;Sci;M. Kuka;M. Iannacone

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淋巴结沿淋巴管沿着战略性定位,充当防止全身病原体传播的过滤站;它们是先天性免疫应答的主要部位,并为适应性免疫的产生提供分期基础。这些淋巴结功能的关键介质是两种表型和功能不同的巨噬细胞亚群:被膜下窦巨噬细胞和髓质巨噬细胞。本文综述了这些淋巴结窦驻留巨噬细胞的表型和功能,并总结了正确识别和实验操作的方法。
Strategically positioned along lymphatic vessels, lymph nodes act as filter stations preventing systemic pathogen dissemination; they are primary sites of innate immune responses and provide the staging grounds for the generation of adaptive immunity. Critical mediators of these lymph node functions are two phenotypically and functionally distinct subsets of macrophages: the subcapsular sinus macrophages and the medullary macrophages. This review focuses on the phenotype and function of these lymph node sinus-resident macrophages and summarizes methods for their proper identification and experimental manipulation.
DOI: --
发表时间: 1994-06
期刊: Development
影响因子: 4.6
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将免疫复合物从被膜下窦转运至非吞噬细胞(包括具有树突状形态的细胞)表面的淋巴结滤泡。
DOI: --
发表时间: 1983
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影响因子: --
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