Conduits mediate transport of low-molecular-weight antigen to lymph node follicles.
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles.
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DOI：
10.1016/j.immuni.2008.12.014
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发表时间：
2009-02-20
期刊：
影响因子：
32.4
通讯作者：
Carroll, Michael C.
中科院分区：
文献类型：
--
作者：
Roozendaal, Ramon;Mempel, Thorsten R.;Pitcher, Lisa A.;Gonzalez, Santiago F.;Verschoor, Admar;Mebius, Reina E.;von Andrian, Ulrich H.;Carroll, Michael C.
最近的研究报道，B细胞直接从被膜下窦巨噬细胞获得大的淋巴携带的抗原和免疫复合物，而小的抗原似乎直接扩散到B细胞滤泡中。为了直接比较大的和小的Ag进入滤泡的入口，我们使用多光子活体显微镜来追踪Ag流入外周淋巴结的引流以及随后在下面的滤泡中与B细胞和滤泡树突状细胞的相遇。我们发现，导管系统延伸到滤泡和介导的小抗原传递到同源B细胞和滤泡树突状细胞。滤泡导管提供了将小抗原递送至B细胞的有效且快速的机制，所述B细胞直接接触富含CXCL 13趋化因子的导管。与此相反，大的抗原结合的包膜下窦巨噬细胞，随后转移到滤泡B细胞如前所述。
Recent studies report that B cells acquire large lymph-borne antigens and immune complexes directly from subcapsular sinus macrophages while small antigens appear to diffuse directly into the B cell follicles. To directly compare entrance of large and small Ags into the follicles, we used multiphoton intravital microscopy to track drainage of Ag into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic cells in the underlying follicles. We find that a system of conduits extends into the follicles and mediates delivery of small antigens to cognate B cells and follicular dendritic cells. The follicular conduits provide an efficient and rapid mechanism for delivery of small antigens to B cells, which directly contact the CXCL13 chemokine-enriched conduits. By contrast, large antigens were bound by subcapsular sinus macrophages and subsequently transferred to follicular B cells as previously reported.
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影响因子：
56.9
作者：
Allen, Christopher D. C.;Okada, Takaharu;Cyster, Jason G.
通讯作者：
Cyster, Jason G.
影响因子：
56.9
作者：
Garside, P;Ingulli, E;Jenkins, MK
通讯作者：
Jenkins, MK
DOI：
10.1084/jem.192.10.1425
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gretz JE;Norbury CC;Anderson AO;Proudfoot AE;Shaw S
通讯作者：
Shaw S
影响因子：
30.5
作者：
Guinamard, R;Okigaki, M;Ravetch, JV
通讯作者：
Ravetch, JV
影响因子：
30.5
作者：
Cinamon, Guy;Zachariah, Marcus A.;Cyster, Jason G.
通讯作者：
Cyster, Jason G.