Autochthonous Outbreak of SARS-CoV-2 Omicron Variant in Booster-Vaccinated (3 Doses) Healthcare Workers in Southern Italy: Just the Tip of the Iceberg?
Autochthonous Outbreak of SARS-CoV-2 Omicron Variant in Booster-Vaccinated (3 Doses) Healthcare Workers in Southern Italy: Just the Tip of the Iceberg?
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DOI：
10.3390/vaccines10020283
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发表时间：
2022-02-13
期刊：
影响因子：
7.8
通讯作者：
Chironna M
中科院分区：
文献类型：
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作者：
Loconsole D;Bisceglia L;Centrone F;Sallustio A;Accogli M;Dalfino L;Brienza N;Chironna M
2021年11月底在意大利首次检测到Omicron关注变异株（VOC），此后尽管意大利人群，尤其是医护人员（HCW）的疫苗覆盖率很高，但VOC仍迅速传播。本研究描述了在15个加强疫苗接种的HCW中爆发的SARS-CoV-2 Omicron感染。2021年12月16日，两名在同一病房工作的医护人员感染SARS-CoV-2。怀疑Omicron VOC是由于分子检测中S基因靶点失败。进一步的调查显示，12月13日参加社交聚会的23名HCW中有15名（65%）感染了Omicron，全基因组测序显示，系统发育树表明这是一个共同的暴露源。其中5名HCW出现轻度症状。在同一病房住院的一名患有多种慢性疾病的病人也被其中一名参与爆发的HCW感染。尽管接种了加强疫苗，但该患者需要ICU治疗。10例受试者在10-19天内达到阴性。在加强疫苗接种受试者中的爆发证实了Omicron VOC的高传播性和免疫逃避。更严格的非药物干预措施，加强剂量的管理和基因组监测是减轻Omicron VOC传播后果的关键长期策略。
The Omicron variant of concern (VOC), first detected in Italy at the end of November 2021, has since spread rapidly, despite high vaccine coverage in the Italian population, especially in healthcare workers (HCWs). This study describes an outbreak of SARS-CoV-2 Omicron infection in 15 booster-vaccinated HCWs. On 16 December 2021, two HCWs working in the same ward were infected with SARS-CoV-2. The Omicron VOC was suspected due to S gene target failure on molecular testing. Further investigation revealed that 15 (65%) of 23 HCWs attending a social gathering on 13 December were infected with Omicron, as shown by whole-genome sequencing, with a phylogenetic tree suggesting a common source of exposure. Five of these HCWs experienced mild symptoms. A patient with multiple chronic conditions hospitalized in the same ward was also infected by one of the HCWs involved in the outbreak. Despite being booster vaccinated, this patient required ICU treatment. Ten subjects achieved negativity in 10–19 days. The outbreak in booster-vaccinated subjects confirms the high transmissibility and immune evasion of the Omicron VOC. More stringent non-pharmaceutical interventions, administration of booster doses, and genomic surveillance are crucial long-term strategies to mitigate the consequences of the spread of the Omicron VOC.
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影响因子：
19
作者：
Singanayagam, Anika;Patel, Monika;Gopal, Robin
通讯作者：
Gopal, Robin
DOI：
10.2807/1560-7917.es.2021.26.50.2101147
发表时间：
2021-12
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Brandal LT;MacDonald E;Veneti L;Ravlo T;Lange H;Naseer U;Feruglio S;Bragstad K;Hungnes O;Ødeskaug LE;Hagen F;Hanch-Hansen KE;Lind A;Watle SV;Taxt AM;Johansen M;Vold L;Aavitsland P;Nygård K;Madslien EH
通讯作者：
Madslien EH
影响因子：
11.8
作者：
Helmsdal, Gunnhild;Hansen, Olga Kristina;Kristiansen, Marnar Fridheim
通讯作者：
Kristiansen, Marnar Fridheim
影响因子：
64.5
作者：
Garcia-Beltran WF;St Denis KJ;Hoelzemer A;Lam EC;Nitido AD;Sheehan ML;Berrios C;Ofoman O;Chang CC;Hauser BM;Feldman J;Roederer AL;Gregory DJ;Poznansky MC;Schmidt AG;Iafrate AJ;Naranbhai V;Balazs AB
通讯作者：
Balazs AB
DOI：
10.1016/j.cmi.2021.05.007
发表时间：
2021-08
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Loconsole D;Sallustio A;Accogli M;Leaci A;Sanguedolce A;Parisi A;Chironna M
通讯作者：
Chironna M