Spatial integration during active tactile sensation drives orientation perception.
Spatial integration during active tactile sensation drives orientation perception.
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DOI：
10.1016/j.neuron.2021.03.020
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发表时间：
2021-05-19
期刊：
影响因子：
16.2
通讯作者：
Adesnik H
中科院分区：
文献类型：
--
作者：
Brown J;Oldenburg IA;Telian GI;Griffin S;Voges M;Jain V;Adesnik H
主动触觉对于物体识别至关重要，但其神经回路基础知之甚少。我们结合了光遗传学，双光子成像和小鼠的高速行为跟踪，解决了基于胡须的物体定向辨别任务。我们发现，方向的歧视需要动物汇总输入从多个胡须特别是沿着胡须弧。动物辨别刺激本身的方向，因为它们的表现对所呈现的刺激的位置是不变的。桶皮质神经元的群体在胡须上求和以编码每个方向。最后，桶皮质的急性光遗传学失活和第4层兴奋性神经元的细胞类型特异性光遗传学抑制降低了性能，这意味着单独的颗粒下层不足以解决任务。这些数据表明，在主动触觉阵列上的空间求和生成对象的取向的表示，这可以促进在主动探索期间对复杂的三维对象的编码。在有源传感器上集成触觉输入对于感知至关重要。Brown，Oldenburg等人表明，小鼠将来自多个触须的触觉输入汇总成弧形，以区分物体的方向。相应地，桶状皮层中的神经元群体整合多须输入来编码物体的方向，并且它们的活动对于任务执行是至关重要的。
Active haptic sensation is critical for object identification, but its neural circuit basis is poorly understood. We combined optogenetics, two-photon imaging, and high-speed behavioral tracking in mice solving a whisker-based object orientation discrimination task. We found that orientation discrimination required animals to summate input from multiple whiskers specifically along the whisker arc. Animals discriminated the orientation of the stimulus per se, as their performance was invariant to the location of the presented stimulus. Populations of barrel cortex neurons summated across whiskers to encode each orientation. Finally, acute optogenetic inactivation of the barrel cortex and cell-type specific optogenetic suppression of layer 4 excitatory neurons degraded performance, implying that infragranular layers alone are not sufficient to solve the task. These data suggest that spatial summation over an active haptic array generates representations of an object’s orientations, which may facilitate the encoding of complex three-dimensional objects during active exploration. The integration of tactile input across active sensors is critical for perception. Brown, Oldenburg et al. show that mice summate tactile input from multiple whiskers in an arc to discriminate the orientation of an object. Correspondingly, populations of neurons in the barrel cortex integrate multi-whisker input to encode the orientation of objects and their activity is critical for task performance.
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