Functional connectivity of the posterior hippocampus is more dominant as we age.
Functional connectivity of the posterior hippocampus is more dominant as we age.
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DOI：
10.1080/17588928.2014.975680
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发表时间：
2014
影响因子：
2
通讯作者：
Stern Y
中科院分区：
文献类型：
--
作者：
Blum S;Habeck C;Steffener J;Razlighi Q;Stern Y
海马体在记忆中的作用取决于它与分布式大脑区域的相互作用。前海马和后海马在记忆加工中具有不同的作用，并且在结构衰退方面受到衰老的不同影响，然而这些海马区域在衰老中的功能连接尚不清楚。年轻（17 - 30岁）和老年（60 - 69岁）认知正常的受试者进行静息态功能MRI显示从年轻时的前海马主导海马连接到老年受试者的后海马主导连接的转变。我们确定了一个子集的新皮层区域，连接到前海马在年轻的成年人，但在老年人的后海马，这表明与年龄相关的重组海马网络支持正常的认知功能。我们还进行了体积分析，结果显示组间无显著结构差异。这些发现为支持正常记忆表现的“功能解剖学”在整个生命周期中发生变化提供了证据。
The role of the hippocampus in memory is dependent on its interaction with distributed brain areas. Anterior and posterior hippocampus have different roles in memory processing, and are impacted differently by aging in terms of structural decline, however functional connectivity of these hippocampal regions in aging is not well understood. Young (age 17-30) and aging (age 60-69) cognitively normal subjects underwent resting-state functional MRI revealing a shift from anterior hippocampus dominant hippocampus connectivity in younger age to posterior hippocampus dominant connectivity in aging subjects. We identified a subset of neocortical regions that are connected to the anterior hippocampus in younger adults but to the posterior hippocampus among older subjects, suggesting an age related reorganization of hippocampal networks supporting normal cognitive function. We also performed volumetric analysis which revealed no significant structural differences between groups. These findings provide evidence that “functional anatomy” which supports normal memory performance changes across the life span.
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影响因子：
3.5
作者：
Mueller, Susanne G.;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
DOI：
10.3233/jad-130011
发表时间：
2013
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Gordon BA;Blazey T;Benzinger TL;Head D
通讯作者：
Head D
影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
影响因子：
3.2
作者：
Shen, Li;Saykin, Andrew J.;Kim, Sungeun;Firpi, Hiram A.;West, John D.;Risacher, Shannon L.;McDonald, Brenna C.;McHugh, Tara L.;Wishart, Heather A.;Flashman, Laura A.
通讯作者：
Flashman, Laura A.
影响因子：
64.8
作者：
Kenet, T;Bibitchkov, D;Arieli, A
通讯作者：
Arieli, A