Comparison of manual and automated determination of hippocampal volumes in MCI and early AD.
Comparison of manual and automated determination of hippocampal volumes in MCI and early AD.
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DOI：
10.1007/s11682-010-9088-x
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发表时间：
2010-03
影响因子：
3.2
通讯作者：
Flashman, Laura A.
中科院分区：
文献类型：
--
作者：
Shen, Li;Saykin, Andrew J.;Kim, Sungeun;Firpi, Hiram A.;West, John D.;Risacher, Shannon L.;McDonald, Brenna C.;McHugh, Tara L.;Wishart, Heather A.;Flashman, Laura A.
关键词：
基于MRI的海马体积分析已被广泛采用，因为其作为脑疾病如阿尔茨海默病（AD）的生物标志物的潜力，并且从脑图像准确和有效地确定海马体积仍然是一个具有挑战性的问题。我们比较了一种自动化的方法，FreeSurfer（V4），与已发表的手动协议，用于确定海马体积的T1加权MRI扫描。我们的研究包括来自125名老年受试者的MRI数据：无明显认知主诉或缺陷的健康对照组（HC，n=38），有认知主诉但神经心理学表现完整的心境正常个体（CC，n=39），以及遗忘型轻度认知障碍（MCI，n=37）或临床诊断为可能AD（AD，n=11）的患者。计算Pearson相关系数和组内相关系数（ICC），以评估手动追踪和FreeSurfer方法结果之间的关系，并估计其一致性。结果表明，这两种方法得到了高度相关的结果与强一致。在统计组分析中控制了年龄、性别和颅内体积后，手动描记和FreeSurfer方法产生了相似的模式：与HC组和CC组相比，MCI组和AD组均显示海马体积减小，HC组和CC组无差异。这些比较表明，FreeSurfer有可能用于自动确定大规模MCI/AD相关MRI研究的海马体积，其中手动方法效率低下或不可行。
MRI-based hippocampal volume analysis has been extensively employed given its potential as a biomarker for brain disorders such as Alzheimer’s disease (AD), and accurate and efficient determination of hippocampal volumes from brain images is still a challenging issue. We compared an automated method, FreeSurfer (V4), with a published manual protocol for the determination of hippocampal volumes from T1-weighted MRI scans. Our study included MRI data from 125 older adult subjects: healthy controls with no significant cognitive complaints or deficits (HC, n=38), euthymic individuals with cognitive complaints (CC, n=39) but intact neuropsychological performance, and patients with amnestic mild cognitive impairment (MCI, n=37) or a clinical diagnosis of probable AD (AD, n=11). Pearson correlations and intraclass correlation coefficients (ICCs) were calculated to evaluate the relationship between results of the manual tracing and FreeSurfer methods and to estimate their agreement. Results indicated that these two methods derived highly correlated results with strong agreement. After controlling for the age, sex and intracranial volume in statistical group analysis, both the manual tracing and FreeSurfer methods yield similar patterns: both the MCI group and the AD group showed hippocampal volume reduction compared to both the HC group and the CC group, and the HC and CC groups did not differ. These comparisons suggest that FreeSurfer has the potential to be used in automated determination of hippocampal volumes for large-scale MCI/AD-related MRI studies, where manual methods are inefficient or not feasible.
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