Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields.
Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields.
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DOI：
10.1002/hipo.20614
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发表时间：
2009-06
期刊：
影响因子：
3.5
通讯作者：
Weiner, Michael W.
中科院分区：
文献类型：
--
作者：
Mueller, Susanne G.;Weiner, Michael W.
组织学研究和动物模型表明，不同的生理和病理生理过程对海马产生不同的亚区特异性影响。在4 T下的高分辨率图像描绘了海马体内部结构的细节，允许海马体子域的体内体积测定。本研究的目的是（1）确定正常老化和载脂蛋白e4携带状态引起的海马子域体积损失模式，（2）确定临床前（MCI）和临床阿尔茨海默病（AD）引起的子域比体积损失及其因年龄和载脂蛋白e4携带状态引起的变化。157名受试者（119名认知健康的老年人对照，20名MCI和18名AD）进行了研究，在4 T下获得的高分辨率T2加权成像序列瞄准海马。95例受试者（66例对照，14例MCI，15例AD）的载脂蛋白e4携带状态已知。手动标记下托（SUB）、CA 1、CA 1-CA 2过渡区（CA 1 -2过渡）、CA 3-齿状回（CA 3和DG）。多元线性回归分析年龄、载脂蛋白e4携带状态、MCI和AD对不同海马亚区的影响。年龄对对照组CA 1、CA 3和DG体积有显著的负性影响（P < 0.05）。AD组海马CA 1区、CA 1 -2区及MCI组CA 1 - 2区移行区体积均明显小于对照组（P < 0.05）。与健康对照组和AD中的非Apo e4携带者相比，Apo e4携带者状态与CA 3和DG中的体积损失相关。基于这些研究结果，我们得出结论，子域容积提供区域选择性的信息，可以区分不同的正常和病理过程影响海马，从而提高神经退行性疾病的鉴别诊断影响海马。
Histopathological studies and animal models suggest that different physiological and pathophysiological processes exert different subfield specific effects on the hippocampus. High-resolution images at 4T depict details of the internal structure of the hippocampus allowing for in vivo volumetry of hippocampal subfields. The aims of this study were (1) to determine patterns of hippocampal subfield volume loss due to normal aging and Apo e4 carrier state, (2) to determine subfield specific volume losses due to preclinical (MCI) and clinical Alzheimer’s disease (AD) and their modification due to age and Apo e4 carrier state. One hundred fifty seven subjects (119 cognitively healthy elderly controls, 20 MCI and 18 AD) were studied with a high resolution T2 weighted imaging sequence obtained at 4T aimed at the hippocampus. Apo e4 carrier state was known in 95 subjects (66 controls, 14 MCI, 15 AD). Subiculum (SUB), CA1, CA1–CA2 transition zone (CA1–2 transition), CA3- dentate gyrus (CA3&DG) were manually marked. Multiple linear regression analysis was used to test for effects of age, Apo e4 carrier state and effects of MCI and AD on different hippocampal subfields. Age had a significant negative effect on CA1 and CA3&DG volumes in controls (P < 0.05). AD had significantly smaller volumes of SUB, CA1, CA1–2 transition, and MCI had smaller CA1–2 transition volumes than controls (P < 0.05). Apo e4 carrier state was associated with volume loss in CA3&DG compared to non-Apo e4 carriers in healthy controls and AD. Based on these findings, we conclude that subfield volumetry provides regional selective information that allows to distinguish between different normal and pathological processes affecting the hippocampus and thus for an improved differential diagnosis of neurodegenerative diseases affecting the hippocampus.
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