Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications.
Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications.
复制标题
用于磁共振成像应用的非均相仲氢诱导乙醚极化。
DOI：
10.1002/chem.202003638
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发表时间：
2021-01-18
期刊：
影响因子：
--
通讯作者：
Koptyug IV
中科院分区：
文献类型：
--
作者：
Salnikov OG;Svyatova A;Kovtunova LM;Chukanov NV;Bukhtiyarov VI;Kovtunov KV;Chekmenev EY;Koptyug IV
使用超极化气体作为造影剂的磁共振成像（MRI）提供了有关肺部结构和功能的宝贵信息。虽然用于临床MRI研究的129Xe超极化技术已经很发达，但需要昂贵的设备来制作和检测超极化的129Xe。在这里，我们提出了乙醚蒸气的1H超极化，可以在任何临床MRI扫描仪上成像。在Rh/TiO2催化剂上，乙基乙烯醚与对氢异相加氢，实现了1H核自旋极化率高达1.3%。乙醚蒸气液化过程中超极化部分保存，使其寿命延长约10倍。以0.1×1.1 mm2的空间分辨率和120 ms的时间分辨率演示了超极化乙醚的2D 1H MRI的原理验证。使用乙醚麻醉的悠久历史有望促进临床翻译提出的方法。气体的核自旋超极化可以提高肺部MRI的分辨率。在Rh/TiO2催化剂上，对氢与乙基乙烯醚成对加成，乙醚麻醉蒸气的1H极化率可达1.3%。通过对乙醚进行液化，可以延长乙醚超极化的寿命。超极化乙醚的MRI显示具有较高的空间和时间分辨率。
Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3% was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ~10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach. Nuclear spin hyperpolarization of gases allows to boost the resolution of pulmonary MRI. Up to 1.3% 1H polarization of diethyl ether anesthetic vapor was obtained using pairwise addition of parahydrogen to ethyl vinyl ether over Rh/TiO2 catalyst. The lifetime of diethyl ether hyperpolarization can be prolonged by its liquefaction. MRI visualization of hyperpolarized diethyl ether was demonstrated with high spatial and temporal resolution.
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影响因子：
3.7
作者：
Ariyasingha, Nuwandi M.;Salnikov, Oleg G.;Chekmenev, Eduard Y.
通讯作者：
Chekmenev, Eduard Y.
DOI：
10.1002/chem.202002528
发表时间：
2020-10-27
期刊：
Chemistry (Weinheim an der Bergstrasse, Germany)
影响因子：
--
作者：
Ariyasingha NM;Joalland B;Younes HR;Salnikov OG;Chukanov NV;Kovtunov KV;Kovtunova LM;Bukhtiyarov VI;Koptyug IV;Gelovani JG;Chekmenev EY
通讯作者：
Chekmenev EY
影响因子：
5.9
作者：
Chen, Mitchell;Doganay, Ozkan;Gleeson, Fergus
通讯作者：
Gleeson, Fergus
影响因子：
3.7
作者：
Barskiy, Danila A.;Kovtunov, Kirill V.;Chekmenev, Eduard Y.
通讯作者：
Chekmenev, Eduard Y.
影响因子：
2.2
作者：
Barskiy, Danila A.;Salnikov, Oleg G.;Chekmenev, Eduard Y.
通讯作者：
Chekmenev, Eduard Y.