Increased expression of BAG-1 in rat brain cortex after traumatic brain injury
Increased expression of BAG-1 in rat brain cortex after traumatic brain injury
复制标题
脑外伤后大鼠大脑皮层BAG-1表达增加
DOI：
10.1007/s10735-012-9408-0
复制
发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Xu T, Wang X,Gong P, Ke K, Gu X.
中科院分区：
文献类型：
--
作者：
Xu T, Wang X,Gong P, Ke K, Gu X.
BAG-1蛋白最初被鉴定为Bcl-2结合蛋白。据报道，BAG-1可增强Bcl-2对细胞死亡的保护，表明BAG-1代表了一种新型的抗细胞死亡基因。此外，最近的研究表明BAG-1可以促进神经前体细胞的增殖，减弱siah 1对神经前体细胞的生长抑制作用。然而，其在中枢神经系统病变中的作用和表达尚不十分清楚。本研究通过建立大鼠创伤性脑损伤（traumatic brain injury，TBI）模型，观察BAG-1在大鼠脑皮层表达的动态变化。免疫荧光双标显示BAG-1与神经元和胶质细胞酸性蛋白（GFAP）共表达。另外，我们检测到增殖细胞核抗原与GFAP、BAG-1有共定位。以上结果提示BAG-1可能参与了TBI后脑组织的病理生理过程。
BAG-1 protein was initially identified as a Bcl-2-binding protein. It was reported to enhance Bcl-2 protection from cell death, suggesting that BAG-1 represents a new type of anti-cell death gene. Moreover, recent study has shown that BAG-1 can enhance the proliferation of neuronal precursor cells, attenuate the growth inhibition induced by siah1. However, its function and expression in the central nervous system lesion are not been understood very well. In this study, we performed a traumatic brain injury (TBI) model in adult rats and investigated the dynamic changes of BAG-1 expression in the brain cortex. Double immunofluorescence staining revealed that BAG-1 was co-expressed with NEURON and glial fibrillary acidic protein (GFAP). In addition, we detected that proliferating cell nuclear antigen had the co-localization with GFAP, and BAG-1. All our findings suggested that BAG-1 might involve in the pathophysiology of brain after TBI.
登录
查看更多内容
影响因子：
--
作者：
Clevenger, CV;Thickman, K;Reed, JC
通讯作者：
Reed, JC
影响因子：
2.6
作者：
Crocoll, A;Blum, M;Cato, ACB
通讯作者：
Cato, ACB
DOI：
10.1093/emboj/16.18.5483
发表时间：
1997-09
期刊：
The EMBO Journal
影响因子：
--
作者：
M. Zeiner;Mathias Gebauer;U. Gehring
通讯作者：
M. Zeiner;Mathias Gebauer;U. Gehring
DOI：
10.1523/jneurosci.17-23-09172.1997
发表时间：
1997-12
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
R. Clark;J. Chen;Simon C Watkins;P. Kochanek;M. Chen;R. A. Stetler;J. E. Loeffert;S. H. Graham
通讯作者：
R. Clark;J. Chen;Simon C Watkins;P. Kochanek;M. Chen;R. A. Stetler;J. E. Loeffert;S. H. Graham
影响因子：
4.2
作者：
Bye, Nicole;Carron, Sarah;Morganti-Kossmann, M. Cristina
通讯作者：
Morganti-Kossmann, M. Cristina