Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L.
Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L.
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使用 EQ-5D-5L 评估肌萎缩侧索硬化症患者的健康相关生活质量
DOI：
10.1186/s12955-021-01822-9
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发表时间：
2021-07-20
影响因子：
3.6
通讯作者：
Shang H
中科院分区：
文献类型：
--
作者：
Wei QQ;Hou Y;Chen Y;Ou R;Cao B;Zhang L;Yang T;Shang H
本研究旨在评价肌萎缩侧索硬化症（ALS）患者的健康相关生活质量（HRQoL），并探讨非运动症状（情绪变化、认知障碍和睡眠障碍）之间的关系。将EQ-5D-5L描述性评分转换为单一汇总“健康效用”评分。采用经校准的视觉模拟量表（EQ-VAS）对当前健康状况进行自我评定。采用多因素Logistic回归分析影响HRQoL的相关因素。在使用EQ-5D-5L评估的547例入组ALS患者中，报告问题的频率最高的是日常活动（76.7%），其次是自我护理（68.8%）和焦虑/抑郁（62.0%）。中位健康效用评分为0.78，中位EQ-VAS评分为70。与EQ-5D-5L健康效用评分差异对应的临床因素包括发病年龄、发病地区、ALS功能评定量表修订版（ALSFRS-R）评分和国王学院分期。抑郁、焦虑和睡眠不佳的患者健康效用评分较低。白天嗜睡过多和快速眼动睡眠行为障碍患者的EQ-VAS评分较低。多因素Logistic分析表明，ALSFRS-R评分、抑郁和焦虑与健康效用评分相关。在调整其他参数后，ALSFRS-R评分、分期和抑郁与EQ-VAS评分显著相关（P < 0.05）。本研究采用EQ-5D-5L量表中文版，在ALS患者的不同疾病阶段检查HRQoL。我们发现HRQoL与疾病的严重程度和情绪障碍有关。非运动症状的管理可能有助于改善ALS患者的HRQoL。在线版本包含补充材料，可通过10.1186/s12955-021-01822-9获得。
The study aimed to appraise the health-related quality of life (HRQoL) measured by the five-level EuroQol-5 dimensions (EQ-5D-5L) in amyotrophic lateral sclerosis (ALS), and to explore the associations between non-motor symptoms (mood changes, cognitive disturbances and sleep disturbances). EQ-5D-5L descriptive scores were converted into a single aggregated “health utility” score. A calibrated visual analog scale (EQ-VAS) was used for self-rating of current health status. Multiple logistic regression analysis was used to explore the factors associated with HRQoL. Among the 547 enrolled ALS patients who were assessed using EQ-5D-5L, the highest frequency of reported problems was with usual activities (76.7%), followed by self-care (68.8%) and anxiety/depression (62.0%). The median health utility score was 0.78 and the median EQ-VAS score was 70. Clinical factors corresponding to differences in the EQ-5D-5L health utility score included age of onset, onset region, the ALS Functional Rating Scale-Revised (ALSFRS-R) score, and King’s College stages. Patients with depression, anxiety, and poor sleep had lower health utility scores. Patients with excessive daytime sleepiness and rapid eye movement sleep behavior disorder had lower EQ-VAS scores. Multivariate logistic analysis indicated that ALSFRS-R scores, depression, and anxiety were associated with health utility scores. After adjusting other parameters, ALSFRS-R score, stages, and depression were significantly associated with EQ-VAS scores (P < 0.05). This study examined HRQoL in ALS patients using the Chinese version of the EQ-5D-5L scale across different stages of the disease. We found that HRQoL is related to disease severity and to mood disturbances. Management of non-motor symptoms may help improve HRQoL in ALS patients. The online version contains supplementary material available at 10.1186/s12955-021-01822-9.
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DOI：
10.1093/brain/awr351
发表时间：
2012-03
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Roche JC;Rojas-Garcia R;Scott KM;Scotton W;Ellis CE;Burman R;Wijesekera L;Turner MR;Leigh PN;Shaw CE;Al-Chalabi A
通讯作者：
Al-Chalabi A
影响因子：
14.5
作者：
Turner, Martin R.;Barnwell, Jessica;Eisen, Andrew
通讯作者：
Eisen, Andrew
影响因子：
3.5
作者：
Herdman, M.;Gudex, C.;Lloyd, A.;Janssen, M. F.;Kind, P.;Parkin, D.;Bonsel, G.;Badia, X.
通讯作者：
Badia, X.
DOI：
10.3109/21678421.2014.993650
发表时间：
2015-06-01
影响因子：
2.8
作者：
Wei, Qianqian;Chen, Xueping;Shang, Huifang
通讯作者：
Shang, Huifang
影响因子：
4.5
作者：
Moore, Alan;Young, Carolyn A.;Hughes, Dyfrig A.
通讯作者：
Hughes, Dyfrig A.