Bah humbug! Association between sending Christmas cards to trial participants and trial retention: randomised study within a trial conducted simultaneously across eight host trials.
Bah humbug! Association between sending Christmas cards to trial participants and trial retention: randomised study within a trial conducted simultaneously across eight host trials.
复制标题
DOI：
10.1136/bmj-2021-067742
复制
发表时间：
2021-12-14
期刊：
影响因子：
--
通讯作者：
Treweek S
中科院分区：
文献类型：
--
作者：
Coleman E;Arundel C;Clark L;Doherty L;Gillies K;Hewitt C;Innes K;Parker A;Torgerson D;Treweek S
确定在随机对照试验中向受试者发送圣诞卡以提高随访时的留存率的有效性，并探讨同时在多个宿主试验中进行试验中研究（SWAT）的可行性。在8项宿主试验中同时进行随机SWAT。八项随机对照试验，研究包括手术和戒烟在内的各个领域。3223名试验参与者，他们仍然需要至少一次随机对照试验的随访。参与者被随机分配（1：1，每个主机试验分别），要么在2019年12月中旬收到圣诞卡，要么不收到圣诞卡。在其宿主随机对照试验中完成下次随访的受试者比例（留存率）。8项主机随机对照试验的1469名参与者（年龄16-94岁; 70%（n=1033）为女性; 96%（813/847）为白色种族）参与了分析（由于新冠肺炎而缩短）。当单独分析或合并结果时，未发现任何宿主试验两组之间的留存率存在差异的证据（卡组为85.3%（639/749），无卡组为85.4%（615/720）;比值比0.96，95%置信区间0.71 - 1.29; P=0.77）。当比较在收到卡片后30天内应进行随访的参与者时，没有观察到差异（比值比0.96，0.42至2.21）。未发现完成问卷的时间存在差异的证据（风险比1.01，95%置信区间0.91 - 1.13; P=0.80）。这些结果对于事后敏感性分析具有稳健性。这项干预的成本为每位参与者0.76英镑（0.91欧元; 1.02美元），每张卡的碳足迹约为140克二氧化碳当量。这种做法的一个好处是只需提交一份道德操守申请。在随机对照试验中，给参与者寄圣诞卡并不能增加他们的记忆力。然而，在多个随机对照试验中同时进行SWAT是可能的。应更经常地采用这种办法，以建立证据基础，支持征聘和留用战略的选择。虽然没有发现增加保留的证据，但同时在多个宿主试验中嵌入SWAT已被证明是可能的。SWAT存储库https：//www.qub.ac.uk/sites/TheNorthernIrelandNetworkforTrialsMethodologyResearch/FileStore/Filetoupload，846275，en. pdf #search =SWAT%2082.
To determine the effectiveness of sending Christmas cards to participants in randomised controlled trials to increase retention rate at follow-ups, and to explore the feasibility of doing a study within a trial (SWAT) across multiple host trials simultaneously. Randomised SWAT conducted simultaneously across eight host trials. Eight randomised controlled trials researching various areas including surgery and smoking cessation. 3223 trial participants who were still due at least one follow-up from their host randomised controlled trial. Participants were randomised (1:1, separately by each host trial) to either received a Christmas card in mid-December 2019 or to not receive a card. Proportion of participants completing their next follow-up (retention rate) within their host randomised controlled trial. 1469 participants (age 16-94 years; 70% (n=1033) female; 96% (813/847) white ethnicity) across the eight host randomised controlled trials were involved in the analysis (cut short owing to covid-19). No evidence was found of a difference in retention rate between the two arms for any of the host trials when analysed separately or when the results were combined (85.3% (639/749) for cards versus 85.4% (615/720) for no card; odds ratio 0.96, 95% confidence interval 0.71 to 1.29; P=0.77). No difference was observed when comparing just participants who were due a follow-up in the 30 days after receiving the card (odds ratio 0.96, 0.42 to 2.21). No evidence of a difference in time to complete the questionnaire was found (hazard ratio 1.01, 95% confidence interval 0.91 to 1.13; P=0.80). These results were robust to post hoc sensitivity analyses. The cost of this intervention was £0.76 (€0.91; $1.02) per participant, and it will have a carbon footprint of approximately 140 g CO2 equivalent per card. One benefit of this approach was the need to only submit one ethics application. Sending Christmas cards to participants in randomised controlled trials does not increase retention. Undertaking a SWAT within multiple randomised controlled trials at the same time is, however, possible. This approach should be used more often to build an evidence base to support selection of recruitment and retention strategies. Although no evidence of a boost to retention was found, embedding a SWAT in multiple host trials simultaneously has been shown to be possible. SWAT repository https://www.qub.ac.uk/sites/TheNorthernIrelandNetworkforTrialsMethodologyResearch/FileStore/Filetoupload,846275,en.pdf#search=SWAT%2082.
登录
查看更多内容
影响因子：
2.5
作者：
Rick, Jo;Graffy, Jonathan;Bower, Peter
通讯作者：
Bower, Peter
改善临床试验中招聘和保留的干预措施：评估当前实践和未来优先事项的调查和研讨会。
影响因子：
2.5
作者：
Bower P;Brueton V;Gamble C;Treweek S;Smith CT;Young B;Williamson P
通讯作者：
Williamson P
影响因子：
2.9
作者：
Ahmed I;Innes K;Brazzelli M;Gillies K;Newlands R;Avenell A;Hernández R;Blazeby J;Croal B;Hudson J;MacLennan G;McCormack K;McDonald A;Murchie P;Ramsay C
通讯作者：
Ramsay C
影响因子：
2.5
作者：
McClinton, Sam;Starr, Kathryn;Wiseman, Oliver
通讯作者：
Wiseman, Oliver
影响因子：
2.5
作者：
Treweek, Shaun;Bevan, Simon;Williamson, Paula R.
通讯作者：
Williamson, Paula R.