Development of modified vaccinia Ankara-5T4 as specific immunotherapy for advanced human cancer.
Development of modified vaccinia Ankara-5T4 as specific immunotherapy for advanced human cancer.
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DOI：
10.1517/14712590802567298
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发表时间：
2008-12
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
肿瘤相关抗原5T4在人类肿瘤中表达的比例很高，在正常组织中表达有限。一种表达该抗原的重组痘痘病毒载体，修饰的安卡拉痘苗(MVA)-5T4，已经作为癌症疫苗进行了测试。已经研究了MVA-5T4在晚期结直肠癌、肾细胞癌（RCC）或激素难治性前列腺癌患者中的单药治疗和与标准化疗、生物或靶向治疗的联合治疗。本综述总结了与MVA-5T4相关的已发表的论文、会议摘要或网站上发表的MVA-5T4临床研究的数据。接种MVA-5T4具有良好的耐受性，在大多数接受治疗的患者中可引起5t4特异性的体液和/或细胞反应。II期研究的回顾性分析表明，5T4免疫应答与良好的临床结果呈正相关。一项正在进行的III期、双盲、安慰剂对照试验旨在证实接种MVA-5T4与晚期RCC患者的生存之间存在正相关。
The tumor-associated antigen 5T4 is expressed on a high percentage of human carcinomas and has limited expression in normal tissues. A recombinant pox virus vector expressing this antigen, modified vaccinia Ankara (MVA)-5T4, has been tested as a cancer vaccine. Treatment with MVA-5T4 has been studied both as a single agent and in combination with standard chemo-, biologic-, or targeted-therapies in patients with advanced colorectal cancer, renal cell carcinoma (RCC), or hormone-refractory prostate cancer. This review summarizes data from clinical studies with MVA-5T4 reported in published manuscripts, meeting abstracts, or posted on websites relevant to clinical trials or MVA-5T4. Vaccination with MVA-5T4 is well tolerated and elicits 5T4-specific humoral and/or cellular responses in the majority of treated patients. Retrospective analyses of phase II studies have suggested a positive association between immune responses to 5T4 and favorable clinical outcomes. An ongoing phase III, double-blind, placebo-controlled trial seeks to confirm a positive association between vaccination with MVA-5T4 and survival in patients with advanced RCC.
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