Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
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雷公藤 F 对寻常型银屑病的疗效和安全性：随机对照试验的系统回顾和荟萃分析
DOI：
10.1155/2018/2623085
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Lu C
中科院分区：
文献类型：
--
作者：
Lv M;Deng J;Tang N;Zeng Y;Lu C
牛皮癣是一种慢性自身免疫介导的皮肤病，其特征是持续性局部红斑鳞状斑块。雷公藤红素（TwHF）是一种著名的中药，在中国已有数百年的历史，用于治疗免疫性疾病、炎症和肿瘤，但具有一定程度的毒性作用。其对牛皮癣的临床疗效和安全性尚不完全清楚。 总结有关 TwHF 治疗银屑病的有效性和安全性的证据。方法。检索截止至2017年10月的EMBASE、Ovid MEDLINE、PubMed、Web of Science、Springer、Cochrane Library、CNKI、CBM、万方、维普数据库。纳入文献由两名独立审稿人评估和提取。为了增强现有证据，我们进行了系统评价，以检查与 TwHF 随机对照试验 (RCT) 相关的所有相关已发表文献。计算相对比（RR）和95％置信区间（CI），并使用RevMan 5.3软件进行荟萃分析。 纳入了 20 项符合条件的 RCT，涉及 1872 名参与者，以进行系统评价和荟萃分析。研究使用 Cochrane 偏倚风险工具进行评估。 TwHF附加效应对银屑病有益的荟萃分析：与复方甘草酸联合治疗（四项研究，OR = 0.34，95% CI 0.22-0.52，P < 0.00001，I2 = 0%），与阿维A联合治疗（三项研究，OR = 0.25，95% CI 0.10-0.63，P = 0.003，I2 = 50%），以及复方氨基多肽片联合治疗（三项研究，OR = 0.37，95% CI 0.22–0.63，P = 0.0002，I2 = 0%）。 尽管 TwHF 有一些轻微的副作用，但有证据表明 TwHF 是治疗牛皮癣的有效方法。然而，由于纳入的试验数量较少，结论受到限制。有必要进行更多精心设计的随机对照试验和广泛的随访期来阐明 TwHF 治疗银屑病的效果和安全性。 该综述已在国际前瞻性系统评价登记册中注册（CRD42016041363）。
Psoriasis is a chronic autoimmune-mediated skin disease that is characterized by persistent localized erythematous scaly plaque. Tripterygium wilfordii Hook F (TwHF), a well-known Chinese medicine that has been used for centuries in China to treat immune diseases, inflammation, and tumor, is accompanied by a degree of toxic effects. Its clinical efficacy and safety on psoriasis are incompletely understood. To summarize evidence concerning the efficacy and safety of TwHF in treating psoriasis. Methods. EMBASE, Ovid MEDLINE, PubMed, Web of Science, Springer, Cochrane Library, CNKI, CBM, Wanfang, and VIP database were searched up to October 2017. The included literature was assessed and extracted by two independent reviewers. To enhance the available evidence, a systematic review was performed to examine all relevant published literature relating to randomized controlled trials (RCTs) of TwHF. Relative ratios (RRs) and 95% confidence intervals (CIs) were calculated, and a meta-analysis was conducted with RevMan 5.3 software. Twenty eligible RCTs with 1872 participants were included for systematic review and meta-analysis. Studies were assessed using the Cochrane risk of bias tool. The meta-analysis of add-on effect of TwHF conferred benefit for psoriasis: combination treatment with compound glycyrrhizin (four studies, OR = 0.34, 95% CI 0.22–0.52, P < 0.00001, I2 = 0%), combination treatment with acitretin (three studies, OR = 0.25, 95% CI 0.10–0.63, P = 0.003, I2 = 50%), and combination treatment with compound amino-polypeptide tablet (three studies, OR = 0.37, 95% CI 0.22–0.63, P = 0.0002, I2 = 0%). Despite several mild side effects of TwHF, there is evidence that TwHF is an effective therapy for psoriasis. However, the conclusions are limited by the small number of included trials. More well-designed RCTs with extensive follow-up periods are warranted to clarify the effects and safety of TwHF in treating psoriasis. This review was registered in the International Prospective Register of Systematic Reviews (CRD42016041363).
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影响因子：
3.3
作者：
Li, Song;Zhu, Jian-Hong;Hang, Chun-Hua
通讯作者：
Hang, Chun-Hua
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG
影响因子：
--
作者：
Li JY;Cao HY;Liu P;Cheng GH;Sun MY
通讯作者：
Sun MY
影响因子：
6.1
作者：
Wu C;Jin HZ;Shu D;Li F;He CX;Qiao J;Yu XL;Zhang Y;He YB;Liu TJ
通讯作者：
Liu TJ
影响因子：
2.2
作者：
Chung, WT;Lee, SH;Lee, HY
通讯作者：
Lee, HY