Geographic determinants of colorectal cancer in Louisiana.
Geographic determinants of colorectal cancer in Louisiana.
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DOI：
10.1007/s10552-021-01546-7
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Wu XC
中科院分区：
文献类型：
--
作者：
Danos D;Leonardi C;Wu XC
目前，美国农村居民因烟草相关癌症和可以通过筛查预防的癌症而承受更大的癌症负担。我们的目标是描述路易斯安那州结直肠癌（CRC）发病率的地理决定因素，包括农村居民和其他已知的地理风险因素、地区社会经济地位（SES）和文化区域（拉丁美洲或法语区）。2008-2017年30岁及以上成人中诊断的原发性结直肠癌来自路易斯安那州肿瘤登记处。人口和社会经济数据来自美国人口普查美国社区调查。农村地区是使用美国农业部2010年城乡通勤区域代码定义的。相对危险度（RR）的估计值来自发病率的多水平二项式回归模型。研究人群中16.1%为农村，18.4%为低社会经济地位，17.9%为埃塞俄比亚人。农村白色居民的CRC风险更高（RR女性：1.09（1.02-1.16），RR男性：1.11（1.04-1.18））。低SES与所有人口统计学群体的CRC增加相关，其超额风险范围从黑人男性的8%（RR：1.08（1.01-1.16））到白色男性的16%（RR：1.16（1.08-1.24））。在埃塞俄比亚地区，黑人男性（RR：1.21（1.10-1.33））和女性（RR：1.21（1.09-1.33））的风险增加最大。在控制了社会经济地位和埃塞俄比亚地区后，CRC的城乡差异不再显著。SES仍然是路易斯安那州CRC差异的一个重要决定因素，并可能导致观察到的城乡差距。虽然CRC风险因素的交叉性是复杂的，但我们已经证实了路易斯安那州路易斯安那州的一个强大的地区差异。在线版本包含补充材料，可通过10.1007/s10552-021-01546-7获得。
Currently, rural residents in the United States (US) experience a greater cancer burden for tobacco-related cancers and cancers that can be prevented by screening. We aim to characterize geographic determinants of colorectal cancer (CRC) incidence in Louisiana due to rural residence and other known geographic risk factors, area socioeconomic status (SES), and cultural region (Acadian or French-speaking). Primary colorectal cancer diagnosed among adults 30 years and older in 2008–2017 were obtained from the Louisiana Tumor Registry. Population and social and economic data were obtained from US Census American Community Survey. Rural areas were defined using US Department of Agriculture 2010 rural–urban commuting area codes. Estimates of relative risk (RR) were obtained from multilevel binomial regression models of incidence. The study population was 16.1% rural, 18.4% low SES, and 17.9% Acadian. Risk of CRC was greater among rural white residents (RR Women: 1.09(1.02–1.16), RR Men: 1.11(1.04–1.18)). Low SES was associated with increased CRC for all demographic groups, with excess risk ranging from 8% in Black men (RR: 1.08(1.01–1.16)) to 16% in white men (RR: 1.16(1.08–1.24)). Increased risk in the Acadian region was greatest for Black men (RR: 1.21(1.10–1.33)) and women (RR: 1.21(1.09–1.33)). Rural–urban disparities in CRC were no longer significant after controlling for SES and Acadian region. SES remains a significant determinant of CRC disparities in Louisiana and may contribute to observed rural–urban disparities in the state. While the intersectionality of CRC risk factors is complex, we have confirmed a robust regional disparity for the Acadian region of Louisiana. The online version contains supplementary material available at 10.1007/s10552-021-01546-7.
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影响因子：
6.2
作者：
Doubeni CA;Laiyemo AO;Major JM;Schootman M;Lian M;Park Y;Graubard BI;Hollenbeck AR;Sinha R
通讯作者：
Sinha R
影响因子：
3.6
作者：
Karlitz, Jordan J.;Blanton, Christine;Fontham, Elizabeth
通讯作者：
Fontham, Elizabeth
影响因子：
24.9
作者：
Henley, S. Jane;Anderson, Robert N.;Richardson, Lisa C.
通讯作者：
Richardson, Lisa C.
影响因子：
4.9
作者：
Bethea, Traci N.;Lopez, Russell P.;McClean, Michael D.
通讯作者：
McClean, Michael D.
DOI：
10.1158/1055-9965.epi-17-0092
发表时间：
2017-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Blake KD;Moss JL;Gaysynsky A;Srinivasan S;Croyle RT
通讯作者：
Croyle RT