Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex.
Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex.
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DOI：
10.1111/j.1460-9568.2009.06624.x
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Flor H
中科院分区：
文献类型：
--
作者：
Lang S;Kroll A;Lipinski SJ;Wessa M;Ridder S;Christmann C;Schad LR;Flor H
功能性磁共振成像用于研究海马体、杏仁核和内侧前额叶皮层 (mPFC) 在引发焦虑的情境调节和消退范式中的作用。二十一名健康人参与了以两种不同背景颜色作为背景的差异背景调节程序。在采集过程中，在左侧海马体和前扣带皮层 (ACC) 中发现条件刺激 (CS+) 的活动相对于 CS− 有所增加。杏仁核、岛叶和下额叶皮层在后期采集过程中的活跃程度存在差异。消退伴随着背侧前扣带皮层 (dACC) 中 CS+ 与 CS− 的激活增强。结果与动物研究一致，并为海马体在人类情境学习中的重要作用提供了证据。连接性分析揭示了早期获取期间左后海马和 dACC (BA32) 以及消退期间 dACC、左后海马和右侧杏仁核之间的相关活动。这些数据与提出 mPFC 对杏仁核具有抑制作用的理论模型一致。 mPFC 与海马体的相互作用可能反映了消退学习的情境特异性。
Functional magnetic resonance imaging was used to investigate the role of the hippocampus, amygdala and medial prefrontal cortex (mPFC) in a contextual conditioning and extinction paradigm provoking anxiety. Twenty-one healthy persons participated in a differential context conditioning procedure with two different background colours as contexts. During acquisition increased activity to the conditioned stimulus (CS+) relative to the CS− was found in the left hippocampus and anterior cingulate cortex (ACC). The amygdala, insula and inferior frontal cortex were differentially active during late acquisition. Extinction was accompanied by enhanced activation to CS+ vs. CS− in the dorsal anterior cingulate cortex (dACC). The results are in accordance with animal studies and provide evidence for the important role of the hippocampus in contextual learning in humans. Connectivity analyses revealed correlated activity between the left posterior hippocampus and dACC (BA32) during early acquisition and the dACC, left posterior hippocampus and right amygdala during extinction. These data are consistent with theoretical models that propose an inhibitory effect of the mPFC on the amygdala. The interaction of the mPFC with the hippocampus may reflect the context-specificity of extinction learning.
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影响因子：
10.6
作者：
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通讯作者：
Grillon, C
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
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