Gut microbiota-immune-brain interactions in chemotherapy-associated behavioral comorbidities.
Gut microbiota-immune-brain interactions in chemotherapy-associated behavioral comorbidities.
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DOI：
10.1002/cncr.31584
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发表时间：
2018-10-15
期刊：
影响因子：
6.2
通讯作者：
Pyter LM
中科院分区：
文献类型：
--
作者：
Jordan KR;Loman BR;Bailey MT;Pyter LM
越来越多的科学关注集中在肠道-脑轴，包括胃肠道(GI)调节中枢神经系统功能的能力。肠道微生物群的变化会影响啮齿动物和人类的情感行为、认知表现、疲劳和睡眠。接受化疗的癌症患者经历类似的负面行为变化和并发的胃肠道症状。这些化疗并发症可能会持续很长时间，并降低患者的生活质量和遵守治疗的动力。本文综述了临床和临床前证据支持肠道微生物群通过外周免疫激活在癌症化疗患者的行为共病中的作用。此外，有证据表明，在癌症治疗期间对肠道微生物群进行有针对性的修改可以改善相关的行为并存。
Increasing scientific attention is focused on the gut-brain axis, including the ability of the gastrointestinal (GI) tract to modulate central nervous system function. Changes in the intestinal microbiome can influence affective-like behavior, cognitive performance, fatigue, and sleep in rodents and humans. Cancer patients receiving chemotherapy experience similar negative behavioral changes and concurrent GI symptoms. These chemotherapy comorbidities can be long-lasting and reduce patients' quality of life and motivation to comply with treatment. This review summarizes the clinical and preclinical evidence supporting a role for the intestinal microbiome in mediating behavioral comorbidities through peripheral immune activation in cancer patients undergoing chemotherapy. In addition, evidence suggesting that targeted modification of the intestinal microbiome during cancer treatment could ameliorate associated behavioral comorbidities is reviewed.
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影响因子：
10.6
作者：
Bruce-Keller AJ;Salbaum JM;Luo M;Blanchard E 4th;Taylor CM;Welsh DA;Berthoud HR
通讯作者：
Berthoud HR
影响因子：
4.6
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Singer, MV
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45.3
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Capuron, L;Ravaud, A;Dantzer, R
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Dantzer, R
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Bower JE;Greendale G;Crosswell AD;Garet D;Sternlieb B;Ganz PA;Irwin MR;Olmstead R;Arevalo J;Cole SW
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Cole SW