A protective effect of lithium on rat behaviour altered by ibotenic acid lesions of the basal forebrain cholinergic system

A protective effect of lithium on rat behaviour altered by ibotenic acid lesions of the basal forebrain cholinergic system
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锂对因鹅膏菌酸损伤基底前脑胆碱能系统而改变的大鼠行为的保护作用

DOI:
10.1016/0006-8993(95)00934-g
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发表时间:
1995
期刊:
影响因子:
2.9
通讯作者:
Jose
Jose
中科院分区:
医学3区
文献类型:
--
作者:
T. Pascual;Jose

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在脑胆碱能兴奋性毒性损伤的动物模型上测试锂。雄性Wistar大鼠接受单侧50 nmol鹅膏蕈氨酸在基底核大细胞。有些人在损伤前2天至损伤后6天腹腔注射LiCl。这种治疗的大鼠表现出比未治疗的损伤动物的被动回避,走动行为和胆碱乙酰转移酶活性的损伤皮层的赤字。锂保护兴奋性氨基酸神经毒性的建议。
Lithium was tested on an animal model of a brain cholinergic excitotoxic lesion. Male Wistar rats received unilaterally 50 nmol ibotenic acid in the nucleus basalis magnocellularis. Some were treated intraperitoneally with LiCl from two days before to six days after lesioning. Such treated rats showed less deficits than untreated lesioned animals on passive avoidance, ambulatory behaviour and choline acetyltransferase activity in the lesioned cortex. Lithium protection against excitatory amino acid neurotoxicity is suggested.
基底前脑神经元和记忆:对鹅膏酯和使君子酯的不同易感性的生化、组织学和行为研究。
DOI: 10.1037//0735-7044.106.6.909
发表时间: 1992
影响因子: 1.9
作者:
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通讯作者: Walker,LC
DOI: 10.1016/s0021-9258(19)70391-3
发表时间: 1980-11
期刊: The Journal of biological chemistry
影响因子: --
作者:
Loretta M. HallcherS;W. Sherman
通讯作者: Loretta M. HallcherS;W. Sherman
DOI: 10.1056/nejm199409013310907
发表时间: 1994-09
期刊: The New England journal of medicine
影响因子: --
作者:
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通讯作者: L. Price;G. Heninger