Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach.
Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach.
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DOI：
10.1371/journal.pone.0126719
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zaretsky DV
中科院分区：
文献类型：
--
作者：
Behrouzvaziri A;Fu D;Tan P;Yoo Y;Zaretskaia MV;Rusyniak DE;Molkov YI;Zaretsky DV
食欲素能神经传递参与介导对甲基苯丙胺（Methe）的温度反应。在大鼠实验中，SB-334867（SB）是一种食欲素受体（OX 1 R）拮抗剂，10 mg/kg剂量的SB-334867（SB）可降低晚期温度反应（t>60 min），而不是中等剂量的Meth 5 mg/kg。较高剂量的SB（30 mg/kg）减弱了对低剂量（1 mg/kg）甲基苯丙胺和应激的温度反应。相比之下，它显着夸大了早期反应（t<60分钟）的中间和高剂量（5和10毫克/公斤）的甲基。由于SB预处理也抑制了注射应力的温度响应，因此难以进行传统的温度响应统计分析。我们已经开发了一个数学模型，解释了温度反应的复杂性，甲基兴奋性和抑制性节点之间的相互作用。我们已经扩展了开发的模型，包括应力的操作和SB的影响。应力是协同与甲基兴奋节点上的行动。食欲素受体介导低剂量Meth对兴奋性和抑制性淋巴结的激活，但不介导高剂量Meth激活的淋巴结。对高剂量甲基苯丙胺的早期反应的夸大涉及去抑制：低剂量的SB降低HD的紧张性抑制并降低激活阈值，而较高剂量抑制抑制成分。使用建模方法的数据同化似乎有效地分离的各个组成部分的复杂的响应与统计分析无法实现传统的数据处理方法。
Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Meth). In experiments in rats, SB-334867 (SB), an antagonist of orexin receptors (OX1R), at a dose of 10 mg/kg decreases late temperature responses (t>60 min) to an intermediate dose of Meth (5 mg/kg). A higher dose of SB (30 mg/kg) attenuates temperature responses to low dose (1 mg/kg) of Meth and to stress. In contrast, it significantly exaggerates early responses (t<60 min) to intermediate and high doses (5 and 10 mg/kg) of Meth. As pretreatment with SB also inhibits temperature response to the stress of injection, traditional statistical analysis of temperature responses is difficult. We have developed a mathematical model that explains the complexity of temperature responses to Meth as the interplay between excitatory and inhibitory nodes. We have extended the developed model to include the stress of manipulations and the effects of SB. Stress is synergistic with Meth on the action on excitatory node. Orexin receptors mediate an activation of on both excitatory and inhibitory nodes by low doses of Meth, but not on the node activated by high doses (HD). Exaggeration of early responses to high doses of Meth involves disinhibition: low dose of SB decreases tonic inhibition of HD and lowers the activation threshold, while the higher dose suppresses the inhibitory component. Using a modeling approach to data assimilation appears efficient in separating individual components of complex response with statistical analysis unachievable by traditional data processing methods.
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影响因子：
2.5
作者：
Kerman, Ilan A.;Bernard, Rene;Watson, Stanley J.
通讯作者：
Watson, Stanley J.
DOI：
10.1152/ajpregu.00365.2013
发表时间：
2014-04-01
期刊：
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
Molkov, Yaroslav I.;Zaretskaia, Maria V.;Zaretsky, Dmitry V.
通讯作者：
Zaretsky, Dmitry V.
影响因子：
--
作者：
Monda, M.;Viggiano, An.;De Luca, V.
通讯作者：
De Luca, V.
影响因子：
3.3
作者：
Blessing, W. W.;Zilm, A.;Ootsuka, Y.
通讯作者：
Ootsuka, Y.
影响因子：
2.2
作者：
KOJIMA, T;UNE, I;YAMAMOTO, K
通讯作者：
YAMAMOTO, K