Continuum modeling of the electric-field-induced tension in deforming lipid vesicles.
Continuum modeling of the electric-field-induced tension in deforming lipid vesicles.
复制标题
脂质囊泡变形过程中电场诱导张力的连续体建模。
DOI:
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发表时间:
2015
影响因子:
4.4
通讯作者:
Petia M. Vlahovska
中科院分区:
文献类型:
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作者:
L. C. McConnell;M. Miksis;Petia M. Vlahovska
We computationally investigate the deformation of a closed bilayer membrane (vesicle) in a DC electric pulse with a goal of understanding cell electroporation. The electric stresses exerted on the area-incompressible interface generate non-uniform tension that can exceed the membrane lysis tension and drive pore opening. Using the two-dimensional boundary integral method, we track the spatial and temporal evolution of the highest membrane tension. Our simulations highlight the dynamic nature of electrotension and, in contrast to the common assumption, a possibility of electroporation away from the poles.
影响因子:
3.4
作者:
DeBruin, KA;Krassowska, W
通讯作者:
Krassowska, W
影响因子:
8.6
作者:
Aranda-Espinoza, H;Bermudez, H;Discher, DE
通讯作者:
Discher, DE
影响因子:
3.4
作者:
NEEDHAM, D;HOCHMUTH, RM
通讯作者:
HOCHMUTH, RM