A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex.
A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex.
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DOI：
10.1016/j.neuron.2011.08.015
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发表时间：
2011-10-06
期刊：
影响因子：
16.2
通讯作者：
Isaacson JS
中科院分区：
文献类型：
--
作者：
Poo C;Isaacson JS
在初级感觉皮层中，有两个主要的兴奋来源：从外周传递的传入感觉输入和反复出现的皮层内输入。解开这两个兴奋性通路的功能作用是理解皮层神经元如何处理感觉刺激的基础。初级嗅觉（梨状）皮层的气味表征依赖于来自嗅球的兴奋性感觉传入。然而，梨状皮质锥体细胞也接受密集的皮质内兴奋性连接，这两条途径对气味反应的相对贡献尚不清楚。使用在体内全细胞电压钳记录和选择性突触沉默的组合，我们表明，招募皮质内输入，而不是嗅球输入，在很大程度上决定了大鼠梨状皮质神经元的气味诱发的兴奋性突触传递的强度。此外，我们发现，皮质内突触占主导地位的气味引起的兴奋性传递在宽调谐神经元，而球突触占主导地位的兴奋性突触反应在更窄的调谐神经元。
In primary sensory cortices, there are two main sources of excitation: afferent sensory input relayed from the periphery, and recurrent intracortical input. Untangling the functional roles of these two excitatory pathways is fundamental for understanding how cortical neurons process sensory stimuli. Odor representations in primary olfactory (piriform) cortex depend on excitatory sensory afferents from the olfactory bulb. However, piriform cortex pyramidal cells also receive dense intracortical excitatory connections and the relative contribution of these two pathways to odor responses is unclear. Using a combination of in vivo whole-cell voltage clamp recording and selective synaptic silencing, we show that the recruitment of intracortical input, rather than olfactory bulb input, largely determines the strength of odor-evoked excitatory synaptic transmission in rat piriform cortical neurons. Furthermore, we find that intracortical synapses dominate odor-evoked excitatory transmission in broadly-tuned neurons, while bulbar synapses dominate excitatory synaptic responses in more narrowly-tuned neurons.
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