Integration of multiscale dendritic spine structure and function data into systems biology models.
Integration of multiscale dendritic spine structure and function data into systems biology models.
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DOI：
10.3389/fnana.2014.00130
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发表时间：
2014
影响因子：
2.9
通讯作者：
Wong ST
中科院分区：
文献类型：
--
作者：
Mancuso JJ;Cheng J;Yin Z;Gilliam JC;Xia X;Li X;Wong ST
人类大脑由1011个神经元和1014个突触连接组成，是系统生物学的终极难题。越来越多的证据表明，大脑功能的变化，无论是正常的还是病理的，始终与神经元解剖学的动态变化相关。解剖学上的变化发生在一个完整的范围内，从单个蛋白质的运输，到单个和系统水平上突触形态的改变，再到长距离连接和脑体积的减少。突触神经元的主要接触部位是树突棘，它为功能神经元回路元件之间的信号连接的数量和强度提供了一个很好的度量。解剖学变化及其功能后果的综合模型将是系统神经科学领域的圣杯，但它的实现似乎遥遥无期。各种成像技术已经发展到允许大脑可塑性和病理学的多尺度可视化，但是对所涉及的大数据集的计算分析形成了创建大脑结构和功能的多尺度模型的瓶颈。虽然对大脑解剖和功能综合模型的技术和进展的全面阐述超出了本文或任何其他论文的范围，这篇综述强调了新的成像技术提供的神经元脊柱解剖和功能分析的机会，同时调查目前可用的计算分析工具和空间的长处和短处，以供将来改进。
Comprising 1011 neurons with 1014 synaptic connections the human brain is the ultimate systems biology puzzle. An increasing body of evidence highlights the observation that changes in brain function, both normal and pathological, consistently correlate with dynamic changes in neuronal anatomy. Anatomical changes occur on a full range of scales from the trafficking of individual proteins, to alterations in synaptic morphology both individually and on a systems level, to reductions in long distance connectivity and brain volume. The major sites of contact for synapsing neurons are dendritic spines, which provide an excellent metric for the number and strength of signaling connections between elements of functional neuronal circuits. A comprehensive model of anatomical changes and their functional consequences would be a holy grail for the field of systems neuroscience but its realization appears far on the horizon. Various imaging technologies have advanced to allow for multi-scale visualization of brain plasticity and pathology, but computational analysis of the big data sets involved forms the bottleneck toward the creation of multiscale models of brain structure and function. While a full accounting of techniques and progress toward a comprehensive model of brain anatomy and function is beyond the scope of this or any other single paper, this review serves to highlight the opportunities for analysis of neuronal spine anatomy and function provided by new imaging technologies and the high-throughput application of older technologies while surveying the strengths and weaknesses of currently available computational analytical tools and room for future improvement.
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影响因子：
7.7
作者：
Bharat, Tanmay A. M.;Malsam, Joerg;Briggs, John A. G.
通讯作者：
Briggs, John A. G.
影响因子：
64.8
作者：
Bock, Davi D.;Lee, Wei-Chung Allen;Kerlin, Aaron M.;Andermann, Mark L.;Hood, Greg;Wetzel, Arthur W.;Yurgenson, Sergey;Soucy, Edward R.;Kim, Hyon Suk;Reid, R. Clay
通讯作者：
Reid, R. Clay
DOI：
10.1007/978-1-59745-520-6_7
发表时间：
2007-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Bower, James M;Beeman, David
通讯作者：
Beeman, David
DOI：
10.1023/a:1024134312173
发表时间：
2002-03-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Benavides-Piccione, R;Ballesteros-Yáñez, I;Yuste, R
通讯作者：
Yuste, R
影响因子：
6.1
作者：
Arion, D;Sabatini, M;DeFelipe, J
通讯作者：
DeFelipe, J