Neurofilament light chain in blood is negatively associated with neuropsychological performance in HIV-infected adults and declines with initiation of antiretroviral therapy.
Neurofilament light chain in blood is negatively associated with neuropsychological performance in HIV-infected adults and declines with initiation of antiretroviral therapy.
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DOI：
10.1007/s13365-018-0664-y
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发表时间：
2018-12
影响因子：
3.2
通讯作者：
Letendre SL
中科院分区：
文献类型：
--
作者：
Anderson AM;Easley KA;Kasher N;Franklin D;Heaton RK;Zetterberg H;Blennow K;Gisslen M;Letendre SL
HIV 相关神经认知障碍 (HAND) 在联合抗逆转录病毒治疗 (cART) 时代持续存在，并与生活质量下降相关。鉴于需要进行全面的神经心理学测试，该疾病的诊断仍然具有挑战性。需要血液生物标志物来促进 HAND 的诊断并评估抗逆转录病毒治疗的神经反应。我们对血浆神经丝轻链 (NFL) 进行了一项研究，其中包括 37 名 HIV 感染者和 54 名 HIV 阴性成年人。在涉及 HIV 感染参与者的单变量混合效应模型中，复合神经心理学评分 (NPT-11) 和血浆 NFL 之间存在统计上显着的线性关系（斜率 = -9.9；标准误差 = 3.0，95% 置信区间：-3.2 至 -16.6，当测试斜率 = 0 时，p = 0.008）。同样，在多变量混合效应模型中，较高的血浆 NFL 与较差的 NPT-11 显着相关（斜率 = -11.5；标准误差 = 3.3，95% 置信区间：-3.7 至 -19.0，当测试斜率 = 0 时，p=0.01）。 NPT-11 和 NFL 之间的关联似乎是由 cART 之外的个体群体推动的。在接受 cART 治疗 24 周之前和之后进行访视的一部分参与者 (n=11) 中，血浆 NFL 随着时间的推移而下降（中位数= 22.7 vs 13.4 pg/ml，p= 0.02）。相比之下，HIV 阴性参与者的血浆 NFL 往往随着时间的推移而增加（中位数为 10.3 与 12.6 pg/ml，p=0.065，n=54）。因此，血浆 NFL 有希望作为 HIV 期间神经心理表现的标志物。需要更大规模的研究来确定 NFL 是否可以作为抑制性 cART 期间 HAND 的诊断工具。
HIV-associated neurocognitive disorder (HAND) persists in the combination antiretroviral therapy (cART) era and is associated with diminished quality of life. The disorder remains challenging to diagnose given the requirement for comprehensive neuropsychological testing. Blood biomarkers are needed to facilitate the diagnosis of HAND and to gauge neurological response to antiretroviral therapy. We performed a study of plasma neurofilament light chain (NFL) that included 37 HIV-infected and 54 HIV-negative adults. In the univariate mixed effects model involving HIV-infected participants, there was a statistically significant linear relationship between composite neuropsychological score (NPT-11) and plasma NFL (slope = −9.9; standard error = 3.0 with 95% confidence interval: −3.2 to −16.6 and p =0.008 when testing slope = 0). Similarly, in the multivariate mixed effects model, higher plasma NFL was significantly associated with worse NPT-11 (slope = −11.5; standard error = 3.3 with 95% confidence interval: −3.7 to −19.0 and p=0.01 when testing slope = 0). The association between NPT-11 and NFL appeared to be driven by the group of individuals off cART. In a subset of participants who had visits before and after 24 weeks on cART (n=11), plasma NFL declined over time (median= 22.7 versus 13.4 pg/ml, p= 0.02). In contrast, plasma NFL tended to increase over time among HIV-negative participants (median 10.3 versus 12.6 pg/ml, p=0.065, n=54). Plasma NFL therefore shows promise as a marker of neuropsychological performance during HIV. Larger studies are needed to determine if NFL could serve as a diagnostic tool for HAND during suppressive cART.
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影响因子：
3.7
作者：
Jessen Krut J;Mellberg T;Price RW;Hagberg L;Fuchs D;Rosengren L;Nilsson S;Zetterberg H;Gisslén M
通讯作者：
Gisslén M
DOI：
10.1038/nrneurol.2016.27
发表时间：
2016-04
期刊：
Nature reviews. Neurology
影响因子：
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作者：
Saylor D;Dickens AM;Sacktor N;Haughey N;Slusher B;Pletnikov M;Mankowski JL;Brown A;Volsky DJ;McArthur JC
通讯作者：
McArthur JC
用于评估有意义的神经心理学变化的基于回归的摘要得分的规范数据和验证。
DOI：
10.1080/13803395.2010.535504
发表时间：
2011-06
影响因子：
2.2
作者：
Cysique LA;Franklin D Jr;Abramson I;Ellis RJ;Letendre S;Collier A;Clifford D;Gelman B;McArthur J;Morgello S;Simpson D;McCutchan JA;Grant I;Heaton RK;CHARTER Group;HNRC Group
通讯作者：
HNRC Group
影响因子：
3.2
作者：
Valcour, Victor;Yee, Priscilla;Sacktor, Ned
通讯作者：
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影响因子：
3.8
作者：
Robertson, Kevin R.;Smurzynski, Marlene;Ellis, Ron J.
通讯作者：
Ellis, Ron J.