Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women.
Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women.
复制标题
抵抗运动对年轻和老年男性和女性肌肉蛋白质合成率的急性影响。
DOI：
10.1152/ajpendo.1993.265.2.e210
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Bier,DM
中科院分区：
文献类型：
--
作者：
Yarasheski,KE;Zachwieja,JJ;Bier,DM
在抗阻运动训练中，老年人的肌肉质量和功能得到改善。这些改善一定是由于肌肉蛋白质合成和分解速率的改变。我们确定了四头肌蛋白质的合成速度，在体内掺入静脉注射[13 C]亮氨酸混合肌肉蛋白在年轻（24岁）和老年人（63 - 66岁）的男性和女性之前和2周的阻力运动训练结束时。训练前，老年人肌肉蛋白质合成分数率低于青年人（0.030 +/-0.003 vs. 0.049 +/-0.004%/h; P = 0.004），但增加（P <0.03）与2周运动后年轻受试者（0.075 +/-0.009%/h）和老年受试者（0.076 +/-0.011%/h）的肌肉蛋白质合成速率相当。在老年人中，肌肉质量，24小时尿3-甲基组氨酸和肌酐排泄量，以及[13 C]亮氨酸输注过程中测定的全身蛋白质分解率在2周的运动后没有变化。这些研究结果表明，在阻力运动训练计划的初始阶段，老年人和年轻人的四头肌蛋白质合成率显着增加，而全身蛋白质分解率没有增加。在老年人中，这并不伴随着尿3-甲基组氨酸排泄的增加，这是肌原纤维蛋白分解的一个指标。
Muscle mass and function are improved in the elderly during resistance exercise training. These improvements must result from alterations in the rates of muscle protein synthesis and breakdown. We determined the rate of quadriceps muscle protein synthesis using the in vivo rate of incorporation of intravenously infused [13C]leucine into mixed-muscle protein in both young (24 yr) and elderly (63-66 yr) men and women before and at the end of 2 wk of resistance exercise training. Before training, the fractional rate of muscle protein synthesis was lower in the elderly than in the young (0.030 +/- 0.003 vs. 0.049 +/- 0.004%/h; P = 0.004) but increased (P < 0.03) to a comparable rate of muscle protein synthesis in both young (0.075 +/- 0.009%/h) and elderly subjects (0.076 +/- 0.011%/h) after 2 wk of exercise. In the elderly, muscle mass, 24-h urinary 3-methylhistidine and creatinine excretion, and whole body protein breakdown rate determined during the [13C]leucine infusion were not changed after 2 wk of exercise. These findings demonstrate that, during the initial phase of a resistance exercise training program, a marked increase in quadriceps muscle protein synthesis rate occurs in elderly and young adults without an increase in the rate of whole body protein breakdown. In the elderly, this was not accompanied by an increase in urinary 3-methylhistidine excretion, an index of myofibrillar protein breakdown.
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影响因子：
3.3
作者：
CHESLEY, A;MACDOUGALL, JD;SMITH, K
通讯作者：
SMITH, K
影响因子：
3.3
作者：
A. Brown;N. McCartney;D. Sale
通讯作者：
D. Sale
DOI：
10.1152/ajpendo.1989.256.2.e288
发表时间：
1989-02
期刊：
The American journal of physiology
影响因子：
--
作者：
N. Fukagawa;K. Minaker;V. Young;D. Matthews;D. Bier;J. Rowe
通讯作者：
N. Fukagawa;K. Minaker;V. Young;D. Matthews;D. Bier;J. Rowe
支链氨基酸的 α-酮酸：简化生理样品的衍生化，并通过填充柱气相色谱法完全分离为喹喔啉醇。
影响因子：
2.9
作者：
Schwarz,HP;Karl,IE;Bier,DM
通讯作者：
Bier,DM
通过毛细管气相色谱/燃烧同位素比质谱法测量肌肉蛋白分数合成率。
DOI：
10.1002/bms.1200211004
发表时间：
1992
期刊：
Biological mass spectrometry
影响因子：
--
作者：
Yarasheski,KE;Smith,K;Rennie,MJ;Bier,DM
通讯作者：
Bier,DM