Fabrication and Characterization of Non-spherical Polymeric Particles
Fabrication and Characterization of Non-spherical Polymeric Particles
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非球形聚合物颗粒的制备和表征
DOI：
10.1007/s12247-020-09484-8
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发表时间：
2020
影响因子：
2.6
通讯作者：
R. Jain
中科院分区：
文献类型：
--
作者：
Ajinkya Patil;Sathish Dyawanapelly;P. Dandekar;R. Jain
颗粒形状是影响药物负载、药物释放、细胞相互作用、细胞摄取以及微米和纳米颗粒的体内分布的关键因素。本研究的目的是通过简单的薄膜拉伸方法从球形纳米颗粒制备非球形颗粒的概念的初步证明。用各种参数优化球形Eudragit® S100 NP，所述参数包括聚合物的浓度、表面活性剂的浓度、有机相-水相比率和均化速度。然后，球形NP嵌入的聚乙烯醇（PVA）薄膜被拉伸，以产生非球形颗粒。最后，分析非球形Eudragit® S100颗粒的所得粒度和表面形态。动态光散射（DLS），扫描电子显微镜（SEM）和透射电子显微镜（TEM）已被用来分析颗粒的大小和形态，薄膜拉伸前后。所得球形NP（< 150 nm）成功地转化为具有精确形状控制的单分散非球形棒状颗粒（< 500 nm）。本研究提供了一种开发非球形Eudragit® S100聚合物颗粒的简单且经济的方法。这些微粒有望成为结肠靶向给药系统或诊断系统。图形摘要图形摘要
The particle shape is a key factor influencing drug loading, drug release, cellular interaction, cell uptake, and in vivo distribution of micro- and nanoparticles. The purpose of the study was to develop a preliminary proof of concept about the fabrication of non-spherical particles from spherical nanoparticles by simple film stretching method. The spherical Eudragit® S100 NPs was optimised with various parameters including, the concentration of the polymer, concentration of the surfactants, organic-aqueous phase ratio, and the speed of homogenization. Then, spherical NP-embedded polyvinyl alcohol (PVA) films were stretched to produce non-spherical particles. Finally, the resulting particle size and surface morphology of non-spherical Eudragit® S100 particles were analysed. Dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) have been utilised to analyse the size and morphology of particles, before and after film stretching. The resulting spherical NPs (< 150 nm) were successfully converted into monodispersed non-spherical, rod-like particles (< 500 nm) with precise shape control. The present study provided a simple and economic method for developing non-spherical Eudragit® S100 polymeric particles. These particles could be used as promising colon-specific drug delivery or diagnostic system. Graphical abstract Graphical abstract
影响因子：
10.8
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
38.3
作者：
Geng, Yan;Dalhaimer, Paul;Discher, Dennis E.
通讯作者：
Discher, Dennis E.