Telomere length in individuals with and without major depression and adverse childhood experiences
Telomere length in individuals with and without major depression and adverse childhood experiences
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有或没有重度抑郁症和不良童年经历的个体的端粒长度
DOI：
10.1016/j.psyneuen.2022.105762
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发表时间：
2022
影响因子：
3.7
通讯作者：
. . . Entringer
中科院分区：
文献类型：
--
作者：
de Punder;Deuter;Martens;. . . Entringer
重度抑郁症（MDD）和不良童年经历（ACE）与成年后的身心健康状况不良有关。一个潜在的机制可能是加速细胞老化。例如，MDD和ACE这两种疾病都与细胞衰老的生物标志物端粒长度（TL）加速缩短有关。由于MDD和ACE在许多研究中混淆，我们的目的是通过本研究进一步理清MDD和ACE对TL的影响，使用全因子设计，包括4组仔细诊断的健康受试者和MDD患者，有和没有ACE（总N = 90，所有未使用抗抑郁药）。作为因变量，在白细胞中评估TL。我们发现TL中MDD和ACE暴露无组间差异。虽然TL与年龄和男性性别呈负相关，但TL与MDD，ACE或当前压力的严重程度无关。我们的空结果的一个可能的解释可能是我们样本的身体健康状况相对较好。未来的研究需要阐明TL，MDD和ACE的关系，考虑药物摄入和身体健康状况的潜在影响。
Major depressive disorder (MDD) and adverse childhood experiences (ACE) are associated with poor physical and mental health in adulthood. One underlying mechanism might be accelerated cellular aging. For example, both conditions, MDD and ACE, have been related to a biological marker of cellular aging, accelerated shortening of telomere length (TL). Since MDD and ACE are confounded in many studies, we aimed with the current study to further disentangle the effects of MDD and ACE on TL using a full-factorial design including four carefully diagnosed groups of healthy participants and MDD patients with and without ACE (total N = 90, all without use of antidepressants). As dependent variable, TL was assessed in leukocytes. We found no group differences based on MDD and ACE exposure in TL. While TL was negatively associated with age and male sex, TL was not associated with any measure of severity of MDD, ACE or current stress. One possible explanation for our null result may be the comparatively good physical health status of our sample. Future research is needed to elucidate the relation of TL, MDD and ACE, taking potential effect modification by medication intake and physical health status into account.
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育亨宾增强去甲肾上腺素能活性和有或没有不良童年经历的重度抑郁症患者的差异性恐惧调节
DOI：
10.1016/j.pnpbp.2019.109751
发表时间：
2020
影响因子：
5.6
作者：
Linn K. Kuehl;Christian E. Deuter;Julian Hellmann-Regen;Michael Kaczmarczyk;Christian Otte;Katja Wingenfeld
通讯作者：
Katja Wingenfeld
DOI：
10.1146/annurev-clinpsy-032816-045054
发表时间：
2018-05-07
影响因子：
18.4
作者：
Epel ES;Prather AA
通讯作者：
Prather AA
DOI：
10.1093/pubmed/fdu065
发表时间：
2015-09
期刊：
Journal of public health (Oxford, England)
影响因子：
--
作者：
Bellis MA;Hughes K;Leckenby N;Hardcastle KA;Perkins C;Lowey H
通讯作者：
Lowey H
影响因子：
120.7
作者：
Heim, C;Newport, DJ;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
6.6
作者：
Ridout KK;Ridout SJ;Price LH;Sen S;Tyrka AR
通讯作者：
Tyrka AR