Tumor‐secreted proliferin‐1 regulates adipogenesis and lipolysis in cachexia
Tumor‐secreted proliferin‐1 regulates adipogenesis and lipolysis in cachexia
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肿瘤分泌的增殖蛋白-1 调节恶病质中的脂肪生成和脂肪分解
DOI：
10.1002/ijc.33418
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发表时间：
2020
影响因子：
6.4
通讯作者：
Hanayama Rikinari
中科院分区：
文献类型：
--
作者：
Nguyen Tuan Duc;Miyatake Yuji;Yoshida Takeshi;Kawahara Hironori;Hanayama Rikinari
癌症相关性恶病质（CAC）是癌症患者的常见综合征，其特征是体重减轻，伴有脂肪和骨骼肌萎缩。代谢变化是CAC的一个关键因素;然而，肿瘤抑制脂肪生成和促进脂解的机制知之甚少。为了阐明这些机制，我们研究了细胞培养系统中肿瘤释放的脂肪生成限制因子。我们确定增殖素-1（PLF-1）是生长激素/催乳素基因家族的成员，是某些肿瘤分泌的一种关键因子，可抑制前脂肪细胞成熟并促进成熟脂肪细胞的脂解。重要的是，移植PLF-1耗尽的肿瘤细胞的小鼠受到保护，免于由于CAC而导致的脂肪损失。这些数据表明，肿瘤分泌的PLF-1在受损的脂肪形成和加速的脂肪分解中起着重要作用，是对抗CAC的潜在治疗靶点。
Cancer‐associated cachexia (CAC) is a common syndrome in cancer patients and is characterized by loss of body weight accompanied by the atrophy of fat and skeletal muscle. Metabolic changes are a critical factor in CAC; however, the mechanisms through which tumors inhibit adipogenesis and promote lipolysis are poorly understood. To clarify these mechanisms, we investigated adipogenesis‐limiting factors released by tumors in a cell culture system. We identified proliferin‐1 (PLF‐1), a member of the growth hormone/prolactin gene family, as a key factor secreted from certain tumors that inhibited preadipocyte maturation and promoted the lipolysis of mature adipocytes. Importantly, mice transplanted with PLF‐1‐depleted tumor cells were protected from fat loss due to CAC. These data show that tumor‐secreted PLF‐1 plays an essential role in impaired adipogenesis and accelerated lipolysis and is a potential therapeutic target against CAC.
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影响因子：
2.9
作者：
Jyhi-Wai Wang;Yan-Nian Jiang;Ching-Ying Huang;Pei-Yu Huang;M. Huang;W. Cheng;Che-Kun James Shen;Y. Ju
通讯作者：
Jyhi-Wai Wang;Yan-Nian Jiang;Ching-Ying Huang;Pei-Yu Huang;M. Huang;W. Cheng;Che-Kun James Shen;Y. Ju
影响因子：
10.5
作者：
Rosen, ED;Hsu, CH;Spiegelman, BM
通讯作者：
Spiegelman, BM
Mrp4，一种新的丝裂原调节蛋白/增殖蛋白基因；
影响因子：
4.8
作者：
Fassett,JT;Hamilton,RT;Nilsen-Hamilton,M
通讯作者：
Nilsen-Hamilton,M
影响因子：
5.9
作者：
Ebadi M;Mazurak VC
通讯作者：
Mazurak VC
DOI：
10.1073/pnas.82.13.4356
发表时间：
1985-01-01
影响因子：
11.1
作者：
LINZER, DIH;LEE, SJ;NATHANS, D
通讯作者：
NATHANS, D