The autonomic nervous system and ventricular arrhythmias in myocardial infarction and heart failure.
The autonomic nervous system and ventricular arrhythmias in myocardial infarction and heart failure.
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DOI:
10.1111/pace.13856
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发表时间:
2020-02
期刊:
影响因子:
--
通讯作者:
Vaseghi M
中科院分区:
文献类型:
--
作者:
Wu P;Vaseghi M
Ventricular arrhythmias (VA) can range in presentation from asymptomatic to cardiac arrest and sudden cardiac death (SCD). Sustained ventricular tachycardia/ventricular fibrillation (VT/VF) are a common cause of SCD, accounting for up to 48% of cases in a recent prospective study of out-of-hospital sudden cardiac arrests. The incidence of VT associated with myocardial infarction (MI) ranges between 3.2% and 5.7%, and in association with left ventricular dysfunction. These studies highlight a particularly arrhythmogenic cardiac syncytia in the setting of coronary syndromes and heart failure. In this review, we outline the components of the cardiac autonomic nervous system (ANS) that play an important role in normal cardiac electrophysiology and function. In addition, changes that occur in the setting of cardiac disease including adverse neural remodeling and neurohormonal activation, which significantly contribute to propensity for VT/VF are discussed.
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