Capable Infection of Hepatitis B Virus in Diffuse Large B-cell Lymphoma.
Capable Infection of Hepatitis B Virus in Diffuse Large B-cell Lymphoma.
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乙型肝炎病毒能够感染弥漫性大B细胞淋巴瘤
DOI：
10.7150/jca.24384
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发表时间：
2018
影响因子：
3.9
通讯作者：
Guo L
中科院分区：
文献类型：
--
作者：
Wang Y;Wang H;Pan S;Hu T;Shen J;Zheng H;Xie S;Xie Y;Lu R;Guo L
背景：弥漫性大B细胞淋巴瘤（DLBCL）是非霍奇金淋巴瘤（NHL）最常见的病理类型。它与宿主免疫力和感染状态密切相关。目的：本研究验证了B型肝炎病毒（HBV）感染也与DLBCL相关的假设。研究方法：对DLBCL与HBV感染的相关性进行临床分析，对DLBCL组织进行HBV原位检测，并进行HBV是否感染B淋巴细胞的生物学实验。结果如下：我们的长期临床资料显示，DLBCL患者血清HBV阳性率（23.6%）明显高于中国普通人群（7.2%，P<0.001），尤其是晚期淋巴瘤患者（P=0.003）。此外，HBV在体外可感染B淋巴细胞，并可在细胞内检测到HBV抗原和核酸。B x型肝炎病毒蛋白（HBx）也强烈表达于血清HBV表面抗原（HBsAg）阳性的DLBCL患者的组织中。这些患者对治疗的反应较差，比值比（OR）为3.04。结论：HBV可感染B淋巴细胞。它可能与DLBCL的发展有关，也可能影响治疗效果。
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common pathological type of non-Hodgkin lymphoma (NHL). It is strongly correlated to the host immunity and infection status. Aim: This study tested the hypothesis that hepatitis B virus (HBV) infection is also associated with DLBCL. Methods: Clinical analysis of the correlation between DLBCL and HBV infection, detection of HBV in situ of DLBCL tissue, and biological experiments that determined whether HBV infects B lymphocytes were conducted. Results: Our long-term clinical data showed that the positive rate of serum HBV was significantly increased in DLBCL patients (23.6%) compared to that in the general Chinese population (7.2%, P<0.001), especially in advanced stage lymphoma patients (P=0.003). In addition, HBV could infect B lymphocytes in vitro and the HBV antigen and nucleic acid could be detected intracellularly. Hepatitis B x protein (HBx) was also strongly expressed in tissues from DLBCL patients that were serum HBV surface antigen (HBsAg) positive. These patients responded less well to therapy with an odds ratio (OR) of 3.04. Conclusions: HBV can infect B lymphocytes. It might be related to the development of DLBCL and may also impact the efficacy of treatment.
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